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Exploring future spinal cord injury therapies
Drug Target Review explores five of the latest research developments in the field of spinal cord injury (SCI) repair.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Artificial enzyme catalytic capabilities improved, say researchers
A study has shown that using a particular three-stranded structure can extend the catalytic performance of artificial metalloenzymes.
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CRISPR-Cas3 used to combat C. difficile in lab and mice
Researchers have shown that CRISPR-Cas3 can successfully attack C. difficile in vitro and in mice, by causing DNA damage to the pathogen.
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Muscle cell atlas developed to aid muscular disease and injury research
Researchers have created a new technical resource atlas which maps the 15 distinct cell types involved in muscle repair for disease and therapy research.
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Increasing ion channel function in cancer T cells could be new immunotherapy
Researchers have found that there is less calmodulin binding to ion channels in the T cells from cancer patients, presenting a new immunotherapeutic target.
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Antibodies stimulate microglia to degrade Alzheimer’s amyloid plaques
A novel antibody has been shown to stimulate microglia to degrade amyloid plaques in a murine model of Alzheimer’s disease.
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Proteins vital for hepatitis B infection discovered by researchers
A new study has revealed five factors and proteins that hepatitis B infection needs for replication of its DNA, providing insight into the disease.
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Structure of commonly mutated histone chaperone revealed by new study
Researchers have shown how ATAD2, a histone chaperone protein, may load histones on to DNA in order to create the chromatin structure.
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TAZ gene therapy reverses Barth syndrome in mice
Researchers have successfully treated cardiac dysfuntion in mice models of Barth syndrome by using a gene therapy to replace TAZ.
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Using virtual screening to identify coronavirus treatments
Drug Target Review rounds up the latest updates on research into coronavirus treatments, focusing on virtual screening to find therapies for COVID-19.
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Master controller regions could be targeted for novel Parkinson’s therapies
Scientists have identified two master controller regions that are essential for alpha-synuclein aggregation and could be targeted by future therapies.
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TEX264 protein could be targeted to help protect DNA from damage
Scientists have identified that the TEX264 protein and associated enzymes protect the genome from damage, which could lead to new anti-ageing and neurodegeneration therapies.
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Researchers identify enzyme critical for regulating cell signalling
An enzyme that adds a cell-signalling code to proteins has been identified by researchers, who say their discovery could aid in the development of cancer therapies.
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Stem cells that can grow new bone discovered by researchers
A new population of stem cells that can generate bone has been revealed by researchers, which they say could have implications in regenerative medicine.
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Novel compound to kill malaria parasites developed by researchers
A collaborative team has developed a compound called WM382, which targets two crucial enzymes in the malaria parasite, effectively killing it.