news
Immune cell autophagy discovery could optimise cancer therapies
Researchers reveal importance of IL-15 in T cell autophagy in the liver, presenting a potential strategy to enhance immunotherapies.
List view / Grid view
Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
news
Faster drug discovery could hit ‘undruggable’ targets
A new technique has been developed which has the potential to harness bacteria to produce billions of different drug candidates to treat diseases like cancer.
news
Could Frizzled receptors be the target of new cancer therapeutics?
The G-protein coupled receptor Frizzled, implicated in diseases like cancer, can be targeted with small molecules which could provide the basis for anti-cancer therapeutics, according to researchers.
news
Combination therapy of α -KLOTHO and TGFβR2 improves osteoarthritis
A study has shown that a combination of α-KLOTHO and TGF β receptor 2 (TGFβR2) recovers cartilage in rats with osteoarthritis and could be a new therapy for humans.
news
Researchers develop technique to map protein-drug interactions
A new method of melting proteins has allowed researchers to identify new potential drug targets by revealing protein-drug interactions.
news
New T-cell therapy could provide universal cancer treatment
Researchers have discovered a new type of T-cell receptor that can kill most cancer types while leaving healthy cells unharmed.
news
Dozens of anti-cancer compounds revealed by screening existing drugs
Researchers have screened thousands of existing drug molecules against cancer cell lines to discover almost 50 compounds that combat the condition.
news
Researchers use CRISPR to identify proteins that prevent inflammation
New findings using CRISPR have shown that the IL-4 and IL-13 proteins can protect the body against inflammation from autoimmune diseases.
news
Cell division recreated in a test tube demonstrates TPX2 protein role in cancer
Studies have identified that the TPX2 protein recruits the molecular machinery required for the branching microtubule nucleation process, so could be a target for cancer therapies.
news
Levels of neurogenesis could be a therapeutic target in neurodegenerative disease
Research has identified that regions of the brain can regenerate via neural stem cells and the process of neurogenesis which could provide a new avenue for regenerative therapeutics.
news
PCSK6 enzyme plays a key role in vascular disease, according to research
A new study has demonstrated that the enzyme proprotein convert subtilisin/kexin 6 causes structural and functional remodelling in vascular disease, so could be a new therapeutic target.
news
Mutations in non-coding regions of the cancer genome could drive tumour growth
Research into the role of non-coding DNA in cancer development and progression has identified 30 regions that may contribute to tumour growth, which could be therapeutic targets.
news
Researchers discover potential diet drug strategy without feeling of nausea
A study has revealed a brain circuit in mice that suppresses the need to eat without a feeling of nausea, presenting a new strategy for diet drugs.
news
Metal-based fragment molecule library to screen for drug candidates
Researchers have developed a novel metal-based fragment library of molecules that can be used to screen for new drug candidates.
article
Could novel sex-linked targets provide an autoimmunity therapy?
Recent research into why autoimmune disorders affect women four times more frequently than men has revealed several novel therapeutic targets that may lead to the development of future treatments.
