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Exosomes used by researchers as form of novel gene therapy
A study has demonstrated that exosomes can be used as nanocarriers for therapeutic contents, as a new type of gene therapy.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Multi-omics approach yields novel insight for peanut allergies
Researchers in New York have identified novel genes associated with the severity of peanut allergies and noted how these genes interact with other genes during allergic reactions. The findings could lead to better treatments for peanut allergies.
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New insights found into lupus may help combat the disease
A new study may lead to new treatments for lupus as it has found that, when impaired, a key regulator of the immune system can cause damaging immune system attacks on skin and organs, which are hallmarks of the disease.
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Accurate model of organ scarring created using stem cells in a lab
Researchers have developed a 'scar in a dish' model derived from human stem cells which mimics the progressive scarring that occurs in human organs and has lead to a drug candidate being identified to stop the progression of fibrosis.
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Assay for reading six molecular pathways simultaneously developed
Researchers have developed a luciferase assay that can be used to monitor the effects of treatments on six different molecular targets at once.
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A novel approach to unravelling the mysteries of Alzheimer’s
The heterogenous and dynamic nature of protein aggregates makes them a particularly challenging class of structures to study. In this article, Professor Tuomas Knowles and Dr Sean Devenish present a novel approach to studying protein structures that could aid in understanding the complexities of Alzheimer’s disease and identify future therapeutic…
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Transitioning novel peptide hits into lead compounds
Unlike synthetic compound libraries, natural product hits must be identified and characterised, as the molecule is often unknown. Venom peptides are often inherently stable due to cysteine knots whereas other peptides may not be. Steve and Carol Trim discuss the challenges of the hit-to-lead journey with these non-standard hits.
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Extensive tumour protein analysis reveals new therapy targets
New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.
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Is a universal vaccine against cancer possible?
A new study has presented a potential strategy for a universal human cancer vaccine. This article delves into the researchers’ findings, exploring their methodologies and results.
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Previously unknown role of dendritic cells in inflammation revealed
A study has demonstrated that dendritic cells play a key role in inflammation and how TNF inhibitors can prevent them from fighting infections.
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CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
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New insights into major disease pathways made with protein discovery
A new chemical tool has been used to identify hundreds of modified proteins which allows new insights to major diseases.
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Researchers find 150 possible inhibitors to fight Nipah virus
A group of scientists from India have used 3D imaging of the Nipah virus to discover potential inhibitors for the disease.
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The implication of a dysfunctional proteasome regulator in neurodegenerative disease
Disrupted protein homeostasis from PI31 inactivation may initiate the process of neurodegeneration seen in Alzheimer’s, ALS and other similar diseases, says new research.
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Promising new therapy developed to treat leukaemia
VTP50469, a new targeted therapy for MLL-rearranged leukaemia, shows greater efficacy and fewer side-effects in mice, according to new research.
