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The genetic mutation causing the development of psoriatic arthritis
Mutation in two copies of the IKBKB gene leads to abnormal function of regulatory T cells, causing psoriatic arthritis.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Developing an mRNA therapy for Duchenne muscular dystrophy
In this Q&A, Aki Ko, CEO and co-founder of Elixirgen Therapeutics, elucidates how their new mRNA technology could potentially restore muscle function in those suffering from Duchenne muscular dystrophy.
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Targeting cancer cells in early hypoxia
Inhibiting the LDHA and GOT1 enzymes could prevent cancer cells’ ability to produce energy, without affecting healthy cells.
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Scientists elucidate the mechanism behind middle-aged obesity
New findings show that age-related MC4R+ cilia shortening causes middle-aged obesity and leptin resistance, which could lead to obesity treatment.
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New insights about the influence of STAP-1 on immune cell activation
The new findings could lead to a therapeutic target for immune-related disorders, like multiple sclerosis.
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P47 suppresses metastasis of HER2-positive breast cancer
Results from an in vivo CRISPR knockout screen, targeting genes involved in autophagy, could lead to new therapies.
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How fusion proteins drive paediatric cancer
Researchers discover that fusion proteins and a gene regulatory protein complex interact through disordered domains.
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Breakthrough for pancreatic cancer treatment
Researchers have designed the first small molecule drug targeting K-Ras GD12, which could improve pancreatic cancer outcomes.
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Recurrent urinary tract infections: potential cause discovered
Researchers find that an overgrowth of nerve cells in the bladder could cause rUTIs, which may offer new approaches to manage symptoms.
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Potential for targeted therapies based on the gigaxonin pathway
Researchers have discovered that higher expression of gigaxonin suppresses aggressive growth of human head and neck cancer cells.
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Newly discovered role of AF1q in neuroblastoma
Researchers have identified that AF1q is highly expressed in neuroblastoma, and could be used to destabilise N-Myc.
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Enhancing the collateral network for beneficial reperfusion
Future interventions for ischaemic stroke patients should enhance collateral function to reduce brain haemorrhage and mortality.
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Key insights into vaccine development for herpesviruses
Researchers found that the D48 antibody neutralised HSV-1 virus infection, which could lead to broad-spectrum drug and vaccine development.
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Uncovering the changes to β-cells at the onset of type 1 diabetes
A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.
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Improved gene editing method for mitochondrial genetic diseases
Researchers have developed the world’s first animal model with A-to-G mtDNA edits achieved using engineered TALEDs.