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Polymerised oestrogen shown to protect nervous system cells
Researchers have polymerised oestrogen using a new approach and found it is effective at protecting and regenerating nervous system cells in vitro.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Gene identified in zebrafish effective at repairing heart damage
Researchers have discovered a gene in zebrafish that enables them to successfully recover after cardiac damage, which could be used to repair heart tissues in humans.
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Study reveals how circulating tumour cells target organs
Regulator genes and proteins have been identified on circulating tumour cells in mice which allow them to target other organs in the body.
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Fullerene compounds could be effective therapy against NSCLC
Researchers have used fullerene compounds to cause NSCLC cell death in cell and animal models, which exhibited low toxicity for healthy cells.
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Novel therapeutic strategy reverses autism symptoms in mice
Researchers have discovered a pathway that causes behavioural abnormalities and other hallmarks of autism; they also revealed how to silence this and reverse the symptoms in mice.
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Silencing RNA nanotherapy shows promise in treating pancreatic cancer
Peptide-based nanoparticles have been designed which can suppress pancreatic cancer growth without the toxic side effects.
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New way to target treatment-resistant cancers identified
A new mechanism by which cancer cells become resistant to chemotherapy has been found which could lead to a new target for drugs.
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LVNC congenital heart condition linked to faulty signalling pathway
A new study, which has shown that the congenital heart condition LVNC could be be caused by signalling defects, may lead to potential therapies.
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Making tumour cells stiff could prevent cancer metastasis
A study has demonstrated that the stiffness of cells indicates whether a tumour will spread and inducing this state could help to avoid metastasis.
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Ten genes revealed to contribute to development of schizophrenia
Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.
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Study finds astrocytes critical in progression of Huntington’s disease
The new research shows that astrocytes contribute to Huntington’s disease symptoms, but suppressing a mutation stops the disease from progressing.
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Selective inhibitor could reduce resistance to cancer therapies
A study has found a selective inhibitor for an enzyme that allows cancer cells to mutate and become resistant to treatments.
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Platform may find new options for mental health treatment
A drug discovery platform for mental health treatment could also help to identify mechanisms for the treatment of substance use disorders.
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Mucus has been shown to tame microbes in new study
Glycans, which are found in mucus, have the ability to regulate how microbes behave and could lead to new therapeutics.
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Dementia spreads via connected brain networks, finds study
New findings on dementia reveal that brain atrophy spreads via connected brain networks, rather than simply adjacent areas of the brain.
