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Researchers develop new immuno-oncology technique
A team has used viral gene editing and CRISPR to form a system that marks tumours for destruction, potentially improving immunotherapies.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Cancer-suppressing cells identified in pancreatic cancer
Cells containing Meflin play a role in restraining the progression of pancreatic cancer and could lead to new therapies against the disease.
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Microglia critical for neurodegeneration in mice, study finds
Microglia brain immune cells are vital in conjunction with the APOE4 gene during the development of Alzheimer’s in mouse models, researchers have found.
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‘Tricking’ bacteria could lead to more effective antibiotics
A technique to 'trick' bacteria into revealing pores in their cell walls has been developed and targeting these could make antibiotics more effective.
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Bacterial strain identified that determines fate for rotavirus sufferers
Scientists in the US have identified a particular bacterial strain, Segmented filamentous bacteria (SFB), that can prevent and cure rotavirus in mice.
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Best targets for immunotherapy identified by new model
A new algorithm has been developed which personalises which cancer mutations are best targets for immunotherapy.
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Study reveals potential of gamma delta T cells to combat breast cancer
Researchers have discovered that a specific subset of gamma delta T cells can be found in higher numbers of breast cancer survivor tissue, indicating its role in fighting the condition.
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Research reveals calcium signalling pathway in T cells
A study has uncovered the mechanism behind calcium entry and exit into T cells, which could be used in development of autoimmune disease treatments.
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Antibodies used to treat and reverse MS symptoms in mice
Researchers have identified a protein on the surface of cells that cause MS and have used antibodies as an effective treatment for the condition in mice.
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Protein receptor linked to cell death imaged for the first time
Researchers have imaged an inflammation-related protein receptor on cell membranes which could inform future drug designs to prevent cell death.
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Potential treatment for heart attacks discovered by researchers
Researchers have uncovered a treatment that may be used to treat heart attacks or to prevent heart failure, using the circadian clock.
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NKAP gene mutation linked to rare developmental disease
A study has revealed that a mutation in the NKAP gene causes a rare syndrome, providing researchers with the potential to develop treatments for the condition.
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Researchers discover new pathway to treat Ewing sarcoma
A study has demonstrated that blocking certain receptors in mice reduced Ewing sarcoma growth and metastasis, which could be used within future treatments.
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Protein responsible for muscle degeneration identified
A study has demonstrated that a certain protein is critical in the decline of muscle regeneration, with the researchers also showing how to inhibit this process in mice.
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T cell homing beacons for lungs identified by researchers
Molecules that are critical for T cells to travel to and populate the lungs have been identified which could strengthen vaccines against influenza.
