Scientists elucidate the mechanism behind middle-aged obesity
New findings show that age-related MC4R+ cilia shortening causes middle-aged obesity and leptin resistance, which could lead to obesity treatment.
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A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
New findings show that age-related MC4R+ cilia shortening causes middle-aged obesity and leptin resistance, which could lead to obesity treatment.
The new findings could lead to a therapeutic target for immune-related disorders, like multiple sclerosis.
Results from an in vivo CRISPR knockout screen, targeting genes involved in autophagy, could lead to new therapies.
Researchers discover that fusion proteins and a gene regulatory protein complex interact through disordered domains.
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Researchers find that an overgrowth of nerve cells in the bladder could cause rUTIs, which may offer new approaches to manage symptoms.
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Future interventions for ischaemic stroke patients should enhance collateral function to reduce brain haemorrhage and mortality.
Researchers found that the D48 antibody neutralised HSV-1 virus infection, which could lead to broad-spectrum drug and vaccine development.
A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.
Researchers have developed the world’s first animal model with A-to-G mtDNA edits achieved using engineered TALEDs.
Researchers discovered that NPTX2 protein accumulated in cells containing abnormal TDP-43 in FTD and ALS patients.
Researchers have uncovered the role of the PL-BLA neuronal axis and its potential function in DOP-mediated anxiolytic effects.
Scientists have targeted the SMRT-retinoic acid receptor interaction, which could provide a reversible and non-hormonal male contraceptive method.