news
Newly discovered role of AF1q in neuroblastoma
Researchers have identified that AF1q is highly expressed in neuroblastoma, and could be used to destabilise N-Myc.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Enhancing the collateral network for beneficial reperfusion
Future interventions for ischaemic stroke patients should enhance collateral function to reduce brain haemorrhage and mortality.
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Key insights into vaccine development for herpesviruses
Researchers found that the D48 antibody neutralised HSV-1 virus infection, which could lead to broad-spectrum drug and vaccine development.
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Uncovering the changes to β-cells at the onset of type 1 diabetes
A new study provides more clarity about the immune events surrounding the onset of T1D, including a new mechanism that could be used for β-cell protection.
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Improved gene editing method for mitochondrial genetic diseases
Researchers have developed the world’s first animal model with A-to-G mtDNA edits achieved using engineered TALEDs.
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New cell culture model reveals neurodegeneration mechanisms
Researchers discovered that NPTX2 protein accumulated in cells containing abnormal TDP-43 in FTD and ALS patients.
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DOP-targeted therapies could exert significant anxiolytic effects
Researchers have uncovered the role of the PL-BLA neuronal axis and its potential function in DOP-mediated anxiolytic effects.
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A promising new option for male contraception
Scientists have targeted the SMRT-retinoic acid receptor interaction, which could provide a reversible and non-hormonal male contraceptive method.
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Video: Dianthus for identifying Microcycle® hits
22 February 2024 | By Dr. Reece Gardner
Hear how Dr. Reece Gardner from Curve Therapeutics uses the Dianthus instrument with Spectral Shift technology to validate Microcycle® hits.
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Potential new therapies for primary open-angle glaucoma
Researchers have gained a better understanding of the genes and biological processes that could influence POAG pathogenesis.
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Uncovering the bidirectional relationship between PD and DM
Single-cell RNA analysis provides an immunological explanation for the association between periodontitis and diabetes mellitus.
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The role of anti-viral drug development in a new pandemic era
As humanity faces an impending era of pandemics, global collaboration among governments, organisations and industry is critical. In this article, epidemiologist Dr Jay Varma explores the urgent need for researching and developing drugs to combat a range of epidemic-prone pathogens, and reflects on the increased risk of spillovers and the…
news
Novel target found for CDKL5 deficiency disorder
Scientists have discovered that increasing the levels of the CDKL2 enzyme could stop CDD symptoms developing or worsening.
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New therapeutic targets for stress related disorders
A mechanism by which the immune system influences central nervous system function and behaviour has been discovered.
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eBook: Reveal Cell Function With Single-Cell Resolution
This eBook explores a new means to perform single-cell functional analysis. Uncover the Xdrop®single-cell format workflow with its ability to help identify, quantify, and comprehend immune cell functions at the individual cellular level.
