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Researchers discover bronchospasms mechanisms using microdevice
A ‘bronchi-on-a-chip’ has been created by researchers to identify the processes of bronchospasms which could aid in respiratory disease therapies.
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Drug Targets
A drug target is anything within a living organism to which a drug is directed and/or binds, resulting in a change in its behaviour or function.
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Study uncovers key processes behind MYC cancer gene
Researchers have discovered that MYC cancers use the cell’s machinery to make lipids and identified a lipid signature, which could be exploited in the development of new therapies.
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Organ-on-an-electronic-chip could be used in drug development
Researchers have created a new organoid model that can be used to study systems such as the heart and the effects of drugs on these cells.
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Study identifies novel measles drug target
Researchers have discovered the mechanism behind the viral genome for measles, which could serve as a druggable target.
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Gene linked to rare disorder also regulates key enzyme in Alzheimer’s
A gene associated with a rare balance disorder also regulates the behaviour of an enzyme that increases the risk for Alzheimer's disease.
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Researchers image structure of cancer metastasis target
The structure of a key receptor involved in tumour metastasis has been imaged in a study, providing opportunities to develop cancer treatments.
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Mechanism behind Piezo proteins discovered using imaging technique
A new study has used a combination of imaging methods to understand how the Piezo protein works, improving research into treatments for conditions such as high blood pressure.
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Osteoporosis in mice reversed with new drug target
A pharmaceutical target has been identified by Duke University that, when activated, can reverse bone degradation caused by osteoporosis.
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Revealed autophagy mechanism is potential dementia target
A study has discovered the regulating process behind cell autophagy which could aid in the development of neurodegenerative disease treatments.
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Link between immune cells and Alzheimer’s discovered
Researchers have found that the presence of microglia brain cells allowed plaques to form in the brains of rodents, leading to Alzheimer’s disease.
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Blocking mechanism in skin cancer provides potential drug target
A study has revealed a drug target for skin cancers which regulates the differentiation of cells and the roles they conduct in the body.
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Study finds inhibiting inflammatory pathway could be brain metastasis target
Researchers have revealed a key inflammation mechanism that contributes to melanoma brain metastasis and could be a therapeutic target.
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Key mechanism in tuberculosis survival discovered
A new study has revealed that M. tuberculosis uses a unique type of antacid which gives immune cells indigestion, enabling the bacteria to survive.
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Researchers identify potential enterovirus drug target
A study has discovered a pathway that allows the enterovirus to successfully infect cells and promote genome release which could be a therapeutic target.
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Beyond the phenotype: using AI to better understand disease
Claus Bendtsen at AstraZeneca reveals how AI can be used to improve our understanding of disease, to help identify the causes of conditions and aid in drug discovery.
