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Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
Stem cells are among the most energetically activated, migratory and proliferative sub-populations of tumour cells, according to observations by scholars at the Biomedical Research Centre at the University of Salford.
The covalent modification of proteins by the attachment of ubiquitin (ubiquitination) is best known for its function to label proteins for proteasomal degradation. However, ubiquitination also plays non-proteasomal roles during signal transduction, DNA repair and protein sorting...
Cholesterol is a ubiquitous molecule that, while essential for health, is probably best known as a risk factor for cardiovascular disease. It is also the obligate precursor for a wide range of metabolites, from steroid hormones to bile acids. Although studied for more than 100 years, recently there has been…
30 March 2016 | By Victoria White
Scientists have discovered two enzymes - AIG1 and ADTRP - that appear to play a role in metabolism and inflammation...
10 March 2016 | By
This graphic depicts a new inhibitor, 6S, locking up an enzyme (red) to block the production of hydrogen sulfide (yellow and white). Hydrogen sulfide concentrations have been shown to climb after the onset of a stroke, leaving to brain damage. CREDIT: Matthew Beio, University of Nebraska-Lincoln Researchers have developed a…
12 January 2016 | By Victoria White
The acquisition includes IOmet's comprehensive preclinical pipeline of IDO (indoleamine-2,3-dioxygenase 1), TDO (tryptophan-2,3-dioxygenase), and dual-acting IDO/TDO inhibitors...
15 December 2015 | By Victoria White
There are thought to be as many as 600,000 protein-protein interactions that could be targets for new drugs. The project seeks to analyse and categorise the important features of these interactions...
14 December 2015 | By Victoria White
A new study outlines a way of using antibiotic resistance to find chemicals capable of stopping amyloid formation in amyloid diseases such as Parkinson’s, Alzheimer’s and type II diabetes...
1 December 2015 | By Victoria White
The team from the Broad Institute and the McGovern Institute for Brain Research found that mutations in three amino acids dramatically reduced “off-target” cuts...
10 November 2015 | By Victoria White
The collaborations aim to identify and validate potential new therapeutic targets as well as identify biomarkers...
15 October 2015 | By Victoria White
Researchers have determined that the protein GPR3 might play an important role in alleviating the cognitive deficits of 'amyloid plaques'...
13 October 2015 | By Victoria White
Researchers have found that tamoxifen gives white blood cells a boost, better enabling them to respond to and kill bacteria in laboratory experiments...
28 September 2015 | By Victoria White
The newly described Cpf1 system differs in several important ways from Cas9, with significant implications for research and therapeutics...
24 September 2015 | By Victoria White
Deubiquitylating enzymes (DUBs) are involved in multiple cellular processes, including DNA damage and cell proliferation, and the inhibition of these enzymes has considerable potential for the generation of novel drugs...
21 September 2015 | By Drug Target Review
Included in this issue: Drug Development, Microfluidics, Proteomics, Ion Channels, GPCR, Imaging, Flow Cytometry, Enzymes
