news New CRISPR system could change the scientific landscape 28 September 2015 | By Victoria White The newly described Cpf1 system differs in several important ways from Cas9, with significant implications for research and therapeutics...
news MISSION Therapeutics receives funding for DUB cancer programme 24 September 2015 | By Victoria White Deubiquitylating enzymes (DUBs) are involved in multiple cellular processes, including DNA damage and cell proliferation, and the inhibition of these enzymes has considerable potential for the generation of novel drugs...
article Drug Target Review – Issue #3 2015 21 September 2015 | By Drug Target Review Included in this issue: Drug Development, Microfluidics, Proteomics, Ion Channels, GPCR, Imaging, Flow Cytometry, Enzymes
article Enzymes: Ubiquitin-specific proteases as druggable targets 21 September 2015 | By Anton Simeonov, Mindy Davis (National Institutes of Health) In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
news ESCMID publishes guidelines aimed at preventing build-up of biofilms 2 September 2015 | By Victoria White ESCMID advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms...
news MISSION Therapeutics appoints Dr Michael Koslowski as Chief Medical Officer 1 September 2015 | By Nick Jackson Dr Koslowski brings over 15 years’ experience across biopharmaceutical research and development, specialising in drug target discovery and clinical validation...
news Roche to acquire Kapa Biosystems 19 August 2015 | By Victoria White Roche has signed a definitive agreement to acquire Kapa Biosystems, strengthening Roche's next-generation sequencing product offerings...
news MedImmune and Mirati in lung cancer therapy collaboration 6 August 2015 | By Victoria White MedImmune has entered into an exclusive clinical trial collaboration with Mirati Therapeutics to evaluate durvalumab in combination with mocetinostat...
news Researchers design first artificial ribosome 30 July 2015 | By Victoria White Researchers have engineered a tethered ribosome that may enable the production of new drugs and next-generation biomaterials...
news Researchers uncover epigenetic switches that turn stem cells into endothelial cells 26 June 2015 | By Victoria White UIC Researchers have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells...
news Smart insulin patch could make painful injections a thing of the past for diabetes sufferers 23 June 2015 | By Victoria White Researchers have created the first smart insulin patch that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream...
news Chemists find scalable way to synthesise the potential brain-protecting compound jiadifenolide 16 June 2015 | By Victoria White Chemists have invented the first practical, scalable method for synthesising jiadifenolide, a molecule that may have powerful brain-protecting properties...
article From hype to hope: challenging the norm in lead discovery 10 June 2015 | By Andy Merritt (MRC Technology Centre for Therapeutics Discovery) From the beginning of time in the drug discovery world, the integration of disciplines has driven the identification of new lead molecules. Chemists, pharmacologists and biologists work together to understand a disease state and how to perturb that state back towards a normal healthy condition. However, in the early days…
article Novel approaches to targeting protein tyrosine kinases 10 June 2015 | By Carol Trim (Canterbury Christ Church University), Danielle McCullough (Canterbury Christ Church University) Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal cellular functions such as growth, cell cycle control, proliferation, differentiation, migration, cellular survival and apoptotic induction.
news Analysis of human aqueous humour reveals 386 new proteins as biomarker candidates 1 June 2015 | By Victoria White Researchers analysing human aqueous humour samples have identified 763 proteins – including 386 proteins detected for the first time...
