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Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
2 September 2015 | By Victoria White
ESCMID advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms...
1 September 2015 | By Nick Jackson
Dr Koslowski brings over 15 years’ experience across biopharmaceutical research and development, specialising in drug target discovery and clinical validation...
19 August 2015 | By Victoria White
Roche has signed a definitive agreement to acquire Kapa Biosystems, strengthening Roche's next-generation sequencing product offerings...
6 August 2015 | By Victoria White
MedImmune has entered into an exclusive clinical trial collaboration with Mirati Therapeutics to evaluate durvalumab in combination with mocetinostat...
30 July 2015 | By Victoria White
Researchers have engineered a tethered ribosome that may enable the production of new drugs and next-generation biomaterials...
26 June 2015 | By Victoria White
UIC Researchers have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells...
23 June 2015 | By Victoria White
Researchers have created the first smart insulin patch that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream...
16 June 2015 | By Victoria White
Chemists have invented the first practical, scalable method for synthesising jiadifenolide, a molecule that may have powerful brain-protecting properties...
From the beginning of time in the drug discovery world, the integration of disciplines has driven the identification of new lead molecules. Chemists, pharmacologists and biologists work together to understand a disease state and how to perturb that state back towards a normal healthy condition. However, in the early days…
Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal cellular functions such as growth, cell cycle control, proliferation, differentiation, migration, cellular survival and apoptotic induction.
1 June 2015 | By Victoria White
Researchers analysing human aqueous humour samples have identified 763 proteins – including 386 proteins detected for the first time...
29 May 2015 | By Victoria White
Padlock Therapeutics has entered into an agreement to license intellectual property and a collection of assets targeted at PADs from GSK...
28 May 2015 | By Victoria White
TSRI scientists have been awarded nearly $2.2 million to advance understanding of IP6K1 and develop innovative approaches for the treatment of obesity...
26 May 2015 | By Victoria White
Chemists at The Scripps Research Institute (TSRI) have discovered a broad and strikingly inexpensive method for synthesising amines...
