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Drug Target Review – Issue #3 2015
21 September 2015 | By Drug Target Review
Included in this issue: Drug Development, Microfluidics, Proteomics, Ion Channels, GPCR, Imaging, Flow Cytometry, Enzymes
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Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
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Enzymes: Ubiquitin-specific proteases as druggable targets
In much the same way that kinases and phosphatases attach and remove phosphate groups from proteins to modulate their activity, there are a series of enzymes (E1, E2, E3) that add one or more ubiquitins onto a protein, as well as enzymes that remove them (deubiquitinases; DUBs), thereby regulating their…
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ESCMID publishes guidelines aimed at preventing build-up of biofilms
2 September 2015 | By Victoria White
ESCMID advocates the need for greater education, guidance and research on the build-up, treatment and prevention of biofilms...
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MISSION Therapeutics appoints Dr Michael Koslowski as Chief Medical Officer
1 September 2015 | By Nick Jackson
Dr Koslowski brings over 15 years’ experience across biopharmaceutical research and development, specialising in drug target discovery and clinical validation...
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Roche to acquire Kapa Biosystems
19 August 2015 | By Victoria White
Roche has signed a definitive agreement to acquire Kapa Biosystems, strengthening Roche's next-generation sequencing product offerings...
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MedImmune and Mirati in lung cancer therapy collaboration
6 August 2015 | By Victoria White
MedImmune has entered into an exclusive clinical trial collaboration with Mirati Therapeutics to evaluate durvalumab in combination with mocetinostat...
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Researchers design first artificial ribosome
30 July 2015 | By Victoria White
Researchers have engineered a tethered ribosome that may enable the production of new drugs and next-generation biomaterials...
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Researchers uncover epigenetic switches that turn stem cells into endothelial cells
26 June 2015 | By Victoria White
UIC Researchers have identified a molecular mechanism that directs embryonic stem cells to mature into endothelial cells...
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Smart insulin patch could make painful injections a thing of the past for diabetes sufferers
23 June 2015 | By Victoria White
Researchers have created the first smart insulin patch that can detect increases in blood sugar levels and secrete doses of insulin into the bloodstream...
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Chemists find scalable way to synthesise the potential brain-protecting compound jiadifenolide
16 June 2015 | By Victoria White
Chemists have invented the first practical, scalable method for synthesising jiadifenolide, a molecule that may have powerful brain-protecting properties...
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From hype to hope: challenging the norm in lead discovery
From the beginning of time in the drug discovery world, the integration of disciplines has driven the identification of new lead molecules. Chemists, pharmacologists and biologists work together to understand a disease state and how to perturb that state back towards a normal healthy condition. However, in the early days…
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Novel approaches to targeting protein tyrosine kinases
Protein kinases, a diverse group of cellular enzymes, play fundamental roles in maintaining normal cellular functions such as growth, cell cycle control, proliferation, differentiation, migration, cellular survival and apoptotic induction.
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Analysis of human aqueous humour reveals 386 new proteins as biomarker candidates
1 June 2015 | By Victoria White
Researchers analysing human aqueous humour samples have identified 763 proteins – including 386 proteins detected for the first time...
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Padlock Therapeutics accelerates pipeline development through agreement with GSK
29 May 2015 | By Victoria White
Padlock Therapeutics has entered into an agreement to license intellectual property and a collection of assets targeted at PADs from GSK...
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TSRI scientists win $2.2 million to expand study of IP6K1 to help develop new obesity therapies
28 May 2015 | By Victoria White
TSRI scientists have been awarded nearly $2.2 million to advance understanding of IP6K1 and develop innovative approaches for the treatment of obesity...