news
TSRI chemists devise inexpensive method for synthesising amines
26 May 2015 | By Victoria White
Chemists at The Scripps Research Institute (TSRI) have discovered a broad and strikingly inexpensive method for synthesising amines...
List view / Grid view
Enzymes
Enzymes are macromolecular biological catalysts. Enzymes accelerate, or catalyse, chemical reactions.
news
First cancer-promoting oncogenes discovered in choroid plexus carcinoma
21 May 2015 | By Victoria White
Researchers have identified three genes that play a pivotal role in choroid plexus carcinoma, a discovery that could lead to more effective treatment...
news
Domainex granted US and EU patents for its lead programme, targeting IKK epsilon and TBK1
11 May 2015 | By Victoria White
US and EU Patent Offices have granted Domainex patents for the first generation of inhibitor compounds in its lead programme targeting IKK epsilon and TBK1.
news
New study explores memory-rescuing potential of inhibiting HDACs
29 April 2015 | By Victoria White
Inhibiting HDACs has shown significant potential in stimulating the growth of brain cells and memory restoration in animal models that mimic Alzheimer’s...
news
New signalling pathway discovered in HER2-positive breast cancer
28 April 2015 | By Victoria White
A team at CSHL has published results of experiments that lay bare a previously unknown pathway activated in HER2-positive breast cancer...
news
Nanoparticles could provide a new treatment option for patients with AMD
30 March 2015 | By Victoria White
Around 6.5 million Europeans currently suffer from AMD. Nanoparticles could potentially be used as carriers for drug treatments instead of injections...
news
MISSION Therapeutics appoints Paul Wallace as Chief Business Officer
19 March 2015 | By Victoria White
MISSION Therapeutics announces the appointment of Paul Wallace PhD as Chief Business Officer...
news
Codexis uses its CodeEvolver® protein engineering platform technology to develop an enzyme therapeutic candidate for the potential treatment of phenylketonuria (PKU) via oral administration
8 December 2014 | By Codexis
Codexis, Inc. announced that it has developed a novel enzyme therapeutic product candidate for the potential treatment of phenylketonuria (PKU) via oral administration...
news
World’s first artificial enzymes created using synthetic biology
2 December 2014 | By The Medical Research Council
Medical Research Council scientists have created the world’s first enzymes made from artificial genetic material...
article
Synthetic macrocyclic receptors as tools in drug delivery and drug discovery
Macrocyclic compounds (see Figure 1) have fascinated medicinal chemists for generations. The first ones which have been characterised are the naturally occurring cyclodextrins (CDs), cyclic oligomers of glucose, which can be obtained by bacterial synthesis from starch. Calixarenes (CXs) were among the first man-made macrocycles, followed by crown ethers (Pedersen,…
news
Daiichi Sankyo to acquire Ambit Biosciences
30 September 2014 | By Daiichi Sankyo
Lead compound, Quizartinib, will further build Daiichi Sankyo oncology pipeline...
news
Boehringer Ingelheim’s volasertib showed in a Phase II study an improvement in overall survival in older AML patients
9 July 2014 | By Boehringer Ingelheim
Results from a Phase II study, published in the American Society of Hematology journal Blood, showed patients with previously untreated acute myeloid leukemia aged 65 or older and ineligible for intensive remission induction therapy, lived longer...
article
Targeting the ubiquitin-proteasome system
The ubiquitin-proteasome system (UPS) is a hierarchical enzymatic cascade that plays an essential role in a broad range of cellular pathways and is found in cytoplasmic and nuclear actions of all eukaryotic cells...
article
Collaborative drug discovery: an update on the progress of such initiatives
Despite the ever increasing efforts being expended for drug discovery purposes, the number of approved drugs remains relatively static. A variety of explanations have been provided to explain this observation and initiatives to remedy this situation have been implemented. Many of these initiatives are still works-in-progress and whether these will…