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The human body has an incredible ability to repair itself, both from acute trauma and chronic damage that accumulates as we age. Here, Cameron Lee, Principal Scientist at Tune Therapeutics, reveals the potential of harnessing the body’s natural regenerative capabilities with epigenetic control of stem cells.
Targeting the epigenetic states of specific retroelements in the human genome could mitigate the biological effects of ageing.
In this Q&A, Dr Ronald DePinho of MD Anderson elucidates their preclinical proof-of-concept that adjusting TERT levels could be a viable therapeutic approach for mitigating age-related diseases, such as cancer, heart disease and Alzheimer’s.
Researchers found that tumour beta cells lose their repression marks and express elevated levels of oncogenes.
Epigenetic data assessing the effects of smoking on DNA methylation could serve as biomarkers of exposure effects.
In this Q&A, Keith Murphy, CEO of Organovo, discusses how the shift from animal models to 3D human tissues can transform the preclinical space. Among his many insights, he details the limitations of animal models, how Organovo’s 3D human tissue models facilitate a deeper understanding of genetic expression within specific…
Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.
A new blood panel test reports the tumour fraction and the tumour type of prostate cancer with a high level of accuracy.
An epigenetic pathway is mediated by a certain protein that could potentially reverse vascular remodelling in pulmonary hypertension.
Analysis of cells shows many regions in DNA are differentially activated or inactivated in a cancer-specific manner.
Using DNA barcoding to track cancer cells through time, scientists have shown that the cells have diverse abilities to escape the immune system.
Using computational methods, researchers analysed the most popular CRISPR library designed for human cells and found 3,300 targeted spots that show strong toxic effects.
The researchers have found that the cells lining the heart direct the cardiac muscle to grow until the heart reaches its full size.
A new study in animals has shown that gene editing may be a potential treatment for anxiety and alcohol use disorder in adults who were exposed to binge drinking in their adolescence.
A CRISPR screening tool identified a new target for acute myeloid leukaemia with fewer side effects than current approaches.
