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Researchers develop directed evolution technique
New method for directed evolution could improve gene therapies and generic drug development.
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Gene Therapy
Gene Therapy is the introduction of normal genes into cells in place of missing or defective ones in order to correct genetic disorders.
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Potential cure for HIV revealed through combined therapies
A new study has used combined therapies to eliminate HIV from mice models, providing potential future cures.
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Source of nucleic-acid asymmetry could improve gene therapies
Researchers have analysed the physical origin and biological consequences of DNA-RNA hybrids which could inform gene therapies.
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Gene discovery could make cancer therapies more effective
A recent study has identified the DBC1 gene which leaves cancer cells more exposed to therapies.
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Longest successful gene expression raises hopes for gene editing therapies
A study has reported that genes delivered to rhesus monkeys are still being expressed four years later.
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Biomarkers for potential cancer immunotherapy identified
Researchers have found two biomarkers which play a significant role in the invasion of tumours by T-cells.
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MS treatment potential after condition-causing genes identified
Researchers have found 12 genes which cause MS, creating potential for preventative treatment of the condition.
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EU conditional marketing authorisation announced for ZYNTEGLO
ZYNTEGLO™ is the first gene therapy approved for transfusion-dependent β-thalassemia (TDT).
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Genetic therapy can heal damage caused by a heart attack
Researchers from King's College London have found a method that can induce heart cells to regenerate after a heart attack.
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Colon cancer proteins and gene analysis uncovers potential new treatments
A new study analysing both the entire set of genes and all the proteins produced by colon cancer tissues has revealed a more comprehensive view of the tumour.
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New nanomachines developed to deliver cancer drugs to hard-to-reach areas
In a recent study in mice, researchers have found a way to deliver specific drugs to parts of the body that are exceptionally difficult to access.
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Artificial chemical receptor developed to assist in T cell engineering
Engineered T cell immunotherapy (such as chimeric antigen receptor T cell (CAR-T) and T cell receptor T cell (TCR-T) therapy), could potentially be used as a therapeutic strategy for tumour treatment.
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Scientists home in on microRNA processing for cancer therapies
Research on the mda-7/IL-24 gene has shown that it helps to suppress a majority of cancer types, and now scientists are focusing on how the gene drives this process by influencing microRNAs...
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Gene therapy to reduce deafness in mice
Gene therapy has been used to restore hearing in an adult mouse model of DFNB9 deafness, one of the most frequent cases of congenital genetic deafness...
whitepaper
Application note: Direct measurements of cellular metabolism for identification of mitochondrial drug targets
Drug target identification has a key role in the drug discovery value chain. A critical step in the development of pharmaceuticals is identifying the direct targets of potential drug candidates as well as distinguishing any secondary or off-target effects...