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CRISPR gene editing can cause hundreds of unintended mutations
As CRISPR-Cas9 starts to move into clinical trials, a new study has found that the gene-editing technology can introduce hundreds of unintended mutations into the genome.
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Gene Therapy
Gene Therapy is the introduction of normal genes into cells in place of missing or defective ones in order to correct genetic disorders.
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Breakthrough in better understanding of acute myeloid leukaemia
A study led by the University of Birmingham has made a breakthrough in the understanding of how different genetic mutations cause acute myeloid leukaemia.
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Largest psoriasis meta-analysis to date yields new genetic clues
1-2% of the US population have psoriasis, an immune-mediated disease that causes red, patchy and scaly marks on the skin.
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Control mechanism unveiled for gene that causes Opitz syndrome
Opitz G/BBB (Opitz) syndrome is a hereditary disorder that affects people in different ways, causing malformations in medial (midline) organs and structures, intellectual disability and developmental disorders.
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New gene variant identified in ALS provides treatment hope
A new study shows that a variant in UBQLN4 gene has been associated with Lou Gehrig's disease, or amyotrophic lateral sclerosis (ALS). The study also describes how this gene variant disrupts a cellular process that drives motor neuron development. This new insight opens the door to potential treatment targets for…
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WGS pinpoints DNA mutations to aid feline disorder treatment
Scientists at The University of Missouri-Columbia are using whole genome sequencing in order to identify genetic mutations that cause rare fatal diseases in cats.
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New genes identified in children linked to stress & bipolar disorder
Genetic alterations that can be modulated by stress have been identified in children at high risk for bipolar disorder, according to a new study...
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A new bioinformatics tool to decipher evolutionary biology
Understanding evolution is one of the cornerstones of biology - evolution is, in fact, the sole explanation for life's diversity on our planet. Based on the evolution of proteins, researchers may explain the emergence of new species and functions through genetic changes or how enzymes with novel functions might be…
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Scrib protein identified as a natural suppressor of liver cancer
A protein that typically helps keep cells organised and on task becomes a tumour suppressor in the face of liver cancer, scientists say.
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New chlamydia drug targets discovered using CRISPR and stem cells
Scientists have created an innovative technique for studying how chlamydia interacts with the human immune system...
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New angle of attack on spinal muscular atrophy (SMA)
Spinal muscular atrophy (SMA) in its most severe form is incurable and fatal in early childhood, but now researchers are mounting a multi-pronged attack for patients and their families.
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DNA: discovering a new mechanism of epigenetic inheritance
Scientists have demonstrated the existence of transgenerational epigenetic inheritance (TEI) among Drosophila fruit flies...
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Removing old cells could extend joint health & stop osteoarthritis
In a preclinical study in mice and human cells, researchers report that selectively removing old or 'senescent' cells from joints could stop and even reverse the progression of osteoarthritis.
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New potential treatment for aggressive brain cancer in children
Using state-of-the-art gene editing technology, scientists have discovered a promising target to treat atypical teratoid/rhabdoid tumour (AT/RT) - a highly aggressive and therapy resistant brain tumour that mostly occurs in infants.
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Premature cell differentiation leads to disorders in pancreatic development
Neonatal diabetes mellitus (NDM), or diabetes among infants less than six months of age, is a rare form of diabetes caused by a mutation in genes crusial to the development or function of beta cells. In about half of such cases, the disease becomes permanent (PNDM). Mutations in more than…