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Scientists map networks of disease-associated immune genes
The new immune gene networks have implications for developing immunotherapies and understanding autoimmune diseases.
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Genetic Analysis
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Visualising mRNA molecules in the brains of living mice
Scientists have developed a new imaging technique that allows researchers to see gene expression and mRNA molecules in the brains of live mice in real time.
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Whole genome sequencing in cancer research
A recent whole genome sequencing study has revealed hidden insights into the causes of cancer. In an exclusive article, Dr Andrea Degasperi from the Early Cancer Institute at the University of Cambridge, UK spoke to Drug Target Review's Ria Kakkad about the study's implications and the future of whole genome sequencing.
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Dysfunctional gene leads to potentially treatable deafness
Researchers have found that inherited mutations in the MINAR2 gene causes deafness. The findings suggest that deafness could be treated with genetic therapies.
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New insights into how genetic factors affect body’s immune response in type 1 diabetes
The new study highlights 11 genes which could be considered as potential candidates for novel therapeutics for type 1 diabetes.
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Target protein for diabetes drug linked to reduce the risk of Alzheimer’s disease
Scientists from Karolinska Institutet have found mechanisms associated with a particular diabetes drug that can also help to protect against Alzheimer’s disease.
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Genetic study identifies promising therapeutic targets for migraines
Researchers have found blood proteins that cause migraines and have a shared link with Alzheimer’s disease that could potentially be prevented by repurposing existing therapeutics.
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Integrating genomic data from different ancestries reduces bias in predicting disease risk
Researchers have developed a promising new tool that accurately uses genomic data to predict disease risk across diverse populations.
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Closing the diversity gap in genomics
In this article, Drug Target Review’s Ria Kakkad explores the importance of diverse and inclusive samples in genomic studies with Assistant Professor Lindsay Fernández-Rhodes, Pennsylvania State University.
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New genetic model of Down’s syndrome developed in rats
Scientists have created what they believe is the first rat model of Down’s syndrome. The animal model shares features with human Down’s syndrome, which will allow for efficient testing of new therapies.
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Genes newly linked to ageing and human lifespan
Researchers have found that genes in small organisms, known to extend lifespan, could also impact ageing in humans.
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CRISPR activation screening: finding genes that interact with SARS-CoV-2
Dr Greg Neely, University of Sydney, explains how he and his team used pooled whole genome CRISPR activation screening to identify LRRC15 as a SARS-CoV-2 spike-interacting protein.
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Cancer-promoting gene a potential target for pulmonary hypertension
The new study identified PDZ-binding kinase (PBK) as a promising target for pulmonary hypertension and assessed two PBK inhibitors.
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Researchers investigate gene network to identify “cancer driver genes”
The new study looked at the network of gene-gene interactions associated with cancer onset and progression to identify therapeutic targets.
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Three RNA-expression states may reveal cancer drug susceptibility
Scientists identified three prototypical RNA-expression states and revealed differences in their susceptibility to a variety of cancer drugs.
