news
CRISPR development enables simultaneous gene editing
Using a combination of Cas9 and Cas12a, Canadian researchers have enabled CRISPR methods to edit multiple genes at the same time.
List view / Grid view
Genome Editing
news
TAZ gene therapy reverses Barth syndrome in mice
Researchers have successfully treated cardiac dysfuntion in mice models of Barth syndrome by using a gene therapy to replace TAZ.
news
Researchers create new Cas9 variant to reduce off-target CRISPR edits
A study has shown that altering amino acid residues in Cas9 to produce new variants can produce a vector with increased gene editing specificity.
news
CRISPR ‘minigene’ used to prevent genetic liver disease in mice
Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.
news
Gene editing platform improves vision in blind mice
Mice with congenital blindness have shown significant improvement in vision after undergoing a new gene therapy.
news
DIRC3 tumour suppressor could be a new target for melanoma therapies
A study has shown that long non-coding RNA called DIRC3 can block melanoma growth and could be used to identify new targets for skin cancer therapies.
news
Scientists find leukaemia’s Achilles heel in vitamin B6
A possible new avenue for treatment of Acute Myeloid Leukaemia (AML) has opened up after US scientists pinpoint how the cancer spreads using excessive amounts of vitamin B6.
article
DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.
article
CRISPR: kick-starting the revolution in drug discovery
Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…
article
Championing genomics in the UK
Professor Sir John Bell, Regius Professor of Medicine at the University of Oxford, delivered a speech at the MHRA’s 14th Annual Lecture in London, outlining his vision for the UK life sciences industry. Here, Nikki Withers summarises the key take-home messages from the talk, including how UK researchers and investors…
news
Epigenome editing used to reverse gene mutation in mice
A study has demonstrated the success of changing the genome of mice, regulating the production of the C11orf46 gene.
news
New method to analyse CRISPR editing developed
Researchers have announced the creation of a novel technique for screening CRISPR edits that allows scientists to identify unintended outcomes in the genome.
news
Study shows that CRISPR-Cas9 gene editing has a low risk of mistakes
A study has shown that unintended mutations from gene editing with CRISPR-Cas9 are rare in zebrafish, providing reassurance that this technology is a valid tool with great promise for the treatment of genetic disorders.
news
Researchers find mutation in CUL3 gene responsible for autism
Scientists have shown that the mutated CUL3 gene, which is involved in the cell’s clearance of proteins, plays a role in the development of autism and schizophrenia in mice.
news
New approach to treating incurable leukaemia in children discovered
A new study into the molecular causes of acute lymphoblastic leukaemia could lead to a new target for therapy.