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APOE4 gene variant linked to Alzheimer’s

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

A study reveals why people with the APOE4 gene have a higher risk of the disease...

news

CRISPR approach could limit toxicity of CAR-T therapy in AML

4 June 2018 | By Dr Zara Kassam (Drug Target Review)

New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...

news

RNA-modifying tool corrects genetic diseases

31 May 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have developed a small-molecule-based tool that acts on RNA to selectively delete certain gene products...

news

CRISPR used to destroy the regulatory genes of HIV

21 May 2018 | By Dr Zara Kassam (Drug Target Review)

By destroying the regulatory genes of the AIDS virus HIV-1 using the genome editing system CRISPR/Cas9, researchers have succeeded in blocking the production of HIV-1 by infected cells...

Scientists generate an atlas of the human genome using stem cells

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Scientists generate an atlas of the human genome using stem cells

25 April 2018 | By Drug Target Review

Scientists have generated an atlas of the human genome using a state-of-the-art gene editing technology and human embryonic stem cells, illuminating the roles that our genes play in health and disease.

whitepaper

Application note: CRISPR/Cas9 genome-edited cells express nanoBRET-donor that monitors protein interaction and trafficking

12 April 2018 | By BMG Labtech GmbH, Carl White (Molecular Endocrinology and Pharmacology), Ethan See (The University of Western Australia), Kevin Pfleger (Dimerix Limited)

In this application note, BMG Labtech discuss how the Bioluminescence resonance energy transfer (BRET) is a versatile tool to study interactions and trafficking in proteins.

news

CRISPR helps find new genetic suspects behind ALS/FTD

13 March 2018 | By Dr Zara Kassam (Drug Target Review)

Study provides a roadmap for using CRISPR to investigate neurological disorders...

news

NIH to launch genome editing research program

24 January 2018 | By Dr Zara Kassam (Drug Target Review)

Somatic Cell Genome Editing aims to develop tools for safe and effective genome editing in humans...

news

Super-silenced DNA study hints at new ways to reprogram cells

9 January 2018 | By Drug Target Review

Newly described stretches of super-silenced DNA reveal a fresh approach to reprogram cell identity.

news

Using 3D cell cultures to fight anti-cancer therapy resistance

13 December 2017 | By Dr Zara Kassam (Drug Target Review)

An international team of researchers have developed 3D cell cultures in which genes can be specifically modified to improve the use of targeted anti-cancer drugs...

news

CRISPR-dCas9 reveals surprising insight into breast cancer development

13 November 2017 | By Dr Zara Kassam (Drug Target Review)

Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to become abnormal...

news

CRISPR engineered to edit single RNA letters

26 October 2017 | By Dr Zara Kassam (Drug Target Review)

New 'REPAIR' system edits RNA, rather than DNA, without permanently affecting the genome...

news

Alpha-1 antitrypsin deficiency shows promise in rare liver disease

20 October 2017 | By Dr Zara Kassam (Drug Target Review)

Nuclease-free gene editing has been found to correct mutated cells ...

news

CRISPR-engineered cancer model to test therapeutics

5 October 2017 | By Dr Zara Kassam (Drug Target Review)

A new technique for modelling leukaemia may aid drug discovery...

news

CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer

28 September 2017 | By Dr Zara Kassam (Drug Target Review)

Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...

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