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Genome Editing

Promising new RNA editing technology could be used to treat genetic diseases

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Promising new RNA editing technology could be used to treat genetic diseases

14 February 2022 | By Ria Kakkad (Drug Target Review)

New research by the University of California, San Diego could provide a much simpler way to repair disease-causing mutations in RNA.

news

New model yields promising gene therapy for heart condition

28 January 2022 | By Mandy Parrett (Drug Target Review)

Scientists in Japan have developed a credible heart cell model for arrhythmogenic cardiomyopathy and observed a positive response in the condition using PKP2 gene therapy.

news

Novel DNA-free virus-like particles deliver gene-editing proteins to animal models

24 January 2022 | By Victoria Rees (Drug Target Review)

Researchers have developed a new drug delivery system using virus-like particles to successfully transport gene-editing proteins in pre-clinical studies.

article

CRISPR activation screening: finding genes that interact with SARS-CoV-2

17 January 2022 | By Dr Greg Neely (University of Sydney)

Dr Greg Neely, University of Sydney, explains how he and his team used pooled whole genome CRISPR activation screening to identify LRRC15 as a SARS-CoV-2 spike-interacting protein.

whitepaper

Brochure: Automation drug discovery

11 January 2022 | By Beckman Coulter Inc

Accelerate your drug discovery workflows efficiently and cost-effectively with lab automation solutions from Beckman Coulter Life Sciences.

news

Scientists develop means to boost the power of CRISPR

7 January 2022 | By Mandy Parrett (Drug Target Review)

The capability to edit genes has been transformative in opening therapeutic avenues for hitherto untreatable diseases and aiding biological insight. Scientists have now discovered a way to enhance this process using retrons, making the process more efficient and effective.

whitepaper

Whitepaper: How to monitor and minimise off-target events

6 January 2022 | By Thermo Fisher Scientific – Cell Biology

Whitepaper discusses strategies to optimize various factors that cause off-target events with Invitrogen™ TrueCut™ HiFi Cas9 Protein.

whitepaper

Product hub: Introducing the latest addition to Thermo Fisher Scientific’s genome editing portfolio – Invitrogen^TM TrueCut^TM HiFi Cas9 Protein!

6 January 2022 | By Thermo Fisher Scientific – Cell Biology

Read about the latest addition Invitrogen™ TrueCut™ HiFi Cas9 Protein to support your application and research goals.

news

Nanoparticle delivery of CRISPR enables genome editing of vascular endothelium

6 January 2022 | By Victoria Rees (Drug Target Review)

According to researchers, a new method to deliver CRISPR-Cas9 to vascular endothelial cells could be used to treat many diseases, including COVID-19.

article

Highlights from Drug Target Review’s Cell & Gene Therapy Advancements Online Summit

13 December 2021 | By Drug Target Review

Here, we round up some of the key takeaways from the expert panel discussions at the Cell & Gene Therapy Advancements Online Summit.

article

Improving the safety of CRISPR for the clinic

9 December 2021 | By Dr Danilo Maddalo (Genentech)

Dr Danilo Maddalo from Genentech outlines the main benefits of CRISPR within the clinical realm and highlights some of the safety concerns that must be considered before CRISPR products reach patients.

Man with inflammatory bowel system holding his stomach highlighted in red

news

CRISPR screen unveils enzyme target for inflammatory diseases

19 November 2021 | By Anna Begley (Drug Target Review)

Scientists used a CRISPR-based screen to find that inhibiting MTHFD2 reduces disease severity in inflammatory disease models.

news

New approach improves avoidance of ‘bystander’ edits in CRISPR-base editor treatments

15 November 2021 | By Victoria Rees (Drug Target Review)

Rice University scientists have refined specific CRISPR-base editing strategies to avoid errors that occur during gene editing.

news

bit.bio raises $103 million in first close of Series B financing

9 November 2021 | By bit.bio

The funding will accelerate clinical development of cell therapies using breakthrough gene engineering technology opti-oxTM.

Woman with rheumatoid arthritis chhecking medicines

news

Experimental vaccine a major breakthrough for rheumatoid arthritis

5 October 2021 | By Anna Begley (Drug Target Review)

A protein-based vaccine has proven a promising option to prevent rheumatoid arthritis, improving bone quality in animal models.

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Genome Editing