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WHO and Switzerland launch BioHub for pathogen storage and analysis
The WHO and Swiss Confederation are set to launch a BioHub Facility, intended to facilitate the sharing of pathogens globally.
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Genomic analysis reveals cellular cause of type 1 diabetes
Combining two genomic methodologies, researchers have shown that pancreatic exocrine cells are implicated in type 1 diabetes.
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Novel CRISPR strategy developed for Duchenne muscular dystrophy
A CRISPR gene editing technique has been developed to restore dystrophin, which is missing in many Duchenne muscular dystrophy (DMD) patients.
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Structure of DNA actively involved in genome regulation, study shows
Researchers have shown that topoisomerase TOP2A eliminates negative supercoiling, causing an increase in the number of turns of DNA strands and impacting gene expression.
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Genetic profile of skeleton osteocytes mapped for first time
Researchers have revealed which genes are switched on or off in osteocytes, a bone cell found in the skeleton.
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Team identifies paediatric acute myeloid leukaemia drug target
Researchers have found that the gene mesothelin can be targeted by new antibody-drug conjugates to treat acute myeloid leukaemia in children.
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Gene therapy in Alzheimer’s mouse model preserves learning and memory
A new gene therapy that introduced SynCav1 to the brains of Alzheimer's mouse models was shown to preserve neuronal and synaptic plasticity.
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CRISPR reveals genes involved in zebrafish spinal cord regeneration
A CRISPR-Cas9 method has been used to identify which genes play a role in repairing zebrafish spinal cord injuries.
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UK Government to fund £37 million into genomics projects
UK Health Secretary Matt Hancock has announced £37 million of funding for genomics and data projects to support the life sciences sector.
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Gene changes caused by Spike protein could explain long COVID
Scientists have shown that the SARS-CoV-2 Spike protein can initiate gene expression changes, potentially explaining long COVID symptoms.
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First comprehensive single-cell atlas of human teeth compiled
Using single-cell sequencing technology, researchers have gained insight into the interactions of dental pulp and periodontal cells of teeth.
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Study points to treatment approaches for advanced small-cell lung cancer
Having sequenced samples of advanced small-cell lung cancer, researchers have identified patterns linked to resistance to certain therapies.
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Scientists call for awareness of unintended mutations from CRISPR
Scientists have said that researchers need to be more aware of unintended mutations to human embryos following CRISPR-Cas9 genome editing.
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Scientists develop new CRISPR-based tool to control epigenome
Researchers have used CRISPR to create a new technology that can switch off almost any gene in cells, called CRISPRoff.
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New gene therapy could preserve vision in retinitis pigmentosa patients
Delivering Txnip to mice with retinitis pigmentosa was an effective treatment, making this approach a potential gene therapy for the disease.