news
RBM5: potential drug target for acute myeloid leukaemia
RBM5 removal from cells meant that HOXA9 mRNA levels were greatly reduced, which could lead to therapies targeting HOXA9-driven leukaemia.
List view / Grid view
Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
article
How AI is accelerating the future of precision medicine
Dr Ketan Patel, Clarivate, shares his insights about the use of Real-World Data and genomic biomarker data and discusses how researchers can use these to better detect and diagnose diseases.
news
Unexpected patterns in DNA mutations identified
Disruptions in TP53 and RB1 are key influencers that cause changes in the risk of mutations across chromosomes.
news
Discovery of a previously unknown class of HK-CREs
Using bioinformatics analyses, HK-CREs impact on cellular processes was studied, including their potential as housekeeping tumour suppressors.
news
Investigating the genetic changes of the DDX3X gene
Using saturation genome editing, researchers have created a map of disease-causing mutations for neurodevelopmental disorders and cancer.
news
Mutated DECTIN-1 and its implications for autoimmune disease
A discovery about the mutated protein DECTIN-1, that limits the production of T regulatory cells, could lead to more effective drugs.
news
The IKAROS protein is crucial for B cell development
By mapping the genome, scientists have discovered how IKAROS enables differentiation of hematopoietic stem cells into B cells.
news
Understanding the genetic origins of disease variation
Researchers, using high-resolution mapping and mathematical modelling, have found mechanisms controlling mutation-driven diseases.
news
New algorithm identifies a novel CRISPR-Cas system
Findings of rare CRISPR-linked gene modules and a novel CRISPR-Cas system have promising implications for genomic therapeutics.
whitepaper
Application note: Next-gen protein sequencing rapid ID of COVID variants
Quantum-Si's Next-Generation Protein Sequencing technology on Platinum™, rapidly distinguishes SARS-CoV-2 variants based on amino acid sequence.
article
Foxp3 protein governs regulatory T cell genome structure
Foxp3 alters chromatin architecture of regulatory T cells, meaning Foxp3 could become a target for therapies that modulate immunosuppression.
article
Microbiotica: transforming medicine with microbiome magic
In this interview, Anne Neville, Director at Microbiotica, elaborates on the significance of the Microbiotica Culture Collection (MCC) and Microbiotica Reference Genome Database (MRGD), which are fundamental to the development of live biotherapeutic medicines.
news
Protective mutation found in kidney disease gene
A new discovery about a different protective genetic mutation in apolipoprotein L1 could have major implications for kidney health.
news
Increased pain sensitivity in Neanderthal gene variants
Three gene variants in SCN9A gene, implicated in sensory neurons and inherited from Neanderthals, result in increased pain sensitivity.
news
Novel based editors developed
Researchers have developed a novel based CRISPR-free base editing system named CyDENT, which enables precise base editing.