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Non-coding RNA may interact with chromatin to control gene expression
The development of an innovative new technology has led researchers to suggest RNA-chromatin interactions may play a role in gene regulation.
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Researchers generate atlas of thymus to understand T-cell development
A new study has created an atlas of human thymus development, to reveal which genes are needed for the production of specific T cells.
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RCAN1 gene revealed as regulator of Down syndrome symptom
A study has shown that the RCAN1 gene plays a role in regulating synaptic plasticity, which contributes to a sympom of Down syndrome.
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New therapy stops seizures in mouse model of rare childhood epilepsy
A rare form of childhood epilepsy could be improved with a therapy called antisense oligonucleotide, following the development of a new model.
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Using blue light to control CAR T cells and destroy tumours
Researchers have created a method to activate CAR T cells with blue LED light to successfully combat solid tumours in mice.
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Key modifier identified in genetic deletion related to autism
A key modifier has been identified by researchers in a large fruit fly genetic deletion related to neurodevelopmental disorders such as schizophrenia and autism.
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CRISPR ‘minigene’ used to prevent genetic liver disease in mice
Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.
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Gene editing platform improves vision in blind mice
Mice with congenital blindness have shown significant improvement in vision after undergoing a new gene therapy.
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Genome screen in mice reveals Huntington’s disease gene target
Researchers have conducted a genetic screen in mice to discover a family of genes that contributes to the development of Huntington's.
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Brain cancer model developed to study glioblastoma
Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.
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Mutations in non-coding regions of the cancer genome could drive tumour growth
Research into the role of non-coding DNA in cancer development and progression has identified 30 regions that may contribute to tumour growth, which could be therapeutic targets.
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Genes associated with heavy alcohol use may also impact compulsive behaviour and addiction
A study suggests there may be common genetic pathways between alcohol use disorder and other addictions, so GWAS identification of affected genes could provide the targets for new therapies.
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Asthma patient genetic analyses reveals glucocorticoid resistance mutation
A genetic analysis has shown that a mutation in the HSD3B1 gene is connected to glucocorticoid treatment resistance in patients with severe asthma.
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RNA and machine learning: rational design for multidimensional biomarkers
Modern day oncology therapies have seen significant innovation in the last decade. It is high time we commit to using biomarkers that are driven by rational design and the latest computational methods.
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DTR’s news round-up 2019: the stories that defined the year
Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.