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Genomics

Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.

Key modifier identified in genetic deletion related to autism

news

Key modifier identified in genetic deletion related to autism

18 February 2020 | By Rachael Harper (Drug Target Review)

A key modifier has been identified by researchers in a large fruit fly genetic deletion related to neurodevelopmental disorders such as schizophrenia and autism.

news

CRISPR ‘minigene’ used to prevent genetic liver disease in mice

13 February 2020 | By Victoria Rees (Drug Target Review)

Researchers have developed a new CRISPR technique, using a minigene, which was inserted into mouse DNA, resulting in improved liver disease symptoms.

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Gene editing platform improves vision in blind mice

10 February 2020 | By Nikki Withers (Drug Target Review)

Mice with congenital blindness have shown significant improvement in vision after undergoing a new gene therapy.

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Genome screen in mice reveals Huntington’s disease gene target

3 February 2020 | By Victoria Rees (Drug Target Review)

Researchers have conducted a genetic screen in mice to discover a family of genes that contributes to the development of Huntington's.

news

Brain cancer model developed to study glioblastoma

30 January 2020 | By Rachael Harper (Drug Target Review)

Researchers have used stem cells, CRISPR and gene sequencing technology to create the basis of a new brain cancer model that could offer opportunities for drug discovery.

news

Mutations in non-coding regions of the cancer genome could drive tumour growth

20 January 2020 | By Hannah Balfour (Drug Target Review)

Research into the role of non-coding DNA in cancer development and progression has identified 30 regions that may contribute to tumour growth, which could be therapeutic targets.

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Genes associated with heavy alcohol use may also impact compulsive behaviour and addiction

15 January 2020 | By Hannah Balfour (Drug Target Review)

A study suggests there may be common genetic pathways between alcohol use disorder and other addictions, so GWAS identification of affected genes could provide the targets for new therapies.

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Asthma patient genetic analyses reveals glucocorticoid resistance mutation

14 January 2020 | By Victoria Rees (Drug Target Review)

A genetic analysis has shown that a mutation in the HSD3B1 gene is connected to glucocorticoid treatment resistance in patients with severe asthma.

article

RNA and machine learning: rational design for multidimensional biomarkers

9 January 2020 | By Dr Jarret Glasscock (Cofactor Genomics)

Modern day oncology therapies have seen significant innovation in the last decade. It is high time we commit to using biomarkers that are driven by rational design and the latest computational methods.

article

DTR’s news round-up 2019: the stories that defined the year

18 December 2019 | By Drug Target Review

Drug Target Review lists its 10 most popular news stories from 2019, summarising the drug targets that you wanted to read about.

news

Exosomes used by researchers as form of novel gene therapy

17 December 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated that exosomes can be used as nanocarriers for therapeutic contents, as a new type of gene therapy.

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Extensive tumour protein analysis reveals new therapy targets

16 December 2019 | By Hannah Balfour (Drug Target Review)

New research has categorised hundreds of cancers based on their common protein mutations, highlighting cell components and tumour microenvironments as possible new therapy targets.

article

CRISPR: kick-starting the revolution in drug discovery

13 December 2019 | By Dr Pushpanathan Muthuirulan (Harvard University)

Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of…

article

Championing genomics in the UK

12 December 2019 | By Nikki Withers (Drug Target Review)

Professor Sir John Bell, Regius Professor of Medicine at the University of Oxford, delivered a speech at the MHRA’s 14th Annual Lecture in London, outlining his vision for the UK life sciences industry. Here, Nikki Withers summarises the key take-home messages from the talk, including how UK researchers and investors…

news

Epigenome editing used to reverse gene mutation in mice

11 December 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated the success of changing the genome of mice, regulating the production of the C11orf46 gene.

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Genomics