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Mucin 6 gene indicates predisposition to late-onset Alzheimer’s
Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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ELRIG Drug Discovery 2019: looking back to the future
On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.
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Modified CRISPR gene editing tool could improve therapies
New cell experiments show more effective genetic 'cuts' that could one day become the foundation of more effective gene therapies.
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Gene therapy for epilepsy shows promise in animal models
An AAV-delivered gene therapy has demonstrated success in animal models of temporal lobe epilepsy, so could be a therapeutic option for human patients.
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Genetic mutation in monkeys identified as cause of Bardet-Biedl Syndrome
A study has revealed that in rhesus monkeys, a genetic mutation could be the cause of Bardet-Biedl Syndrome, providing a way to study the disease and develop therapies.
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Researchers reveal how body repairs damaged DNA
A team has imaged the process that the body uses to stabilise DNA, which could be used to develop therapies for conditions such as cancer.
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New antiviral drug demonstrated to effectively treat influenza in models
A new antiviral drug has been reported in a study that researchers believe has high clinical potential as a next-generation influenza drug.
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Gene identified in zebrafish effective at repairing heart damage
Researchers have discovered a gene in zebrafish that enables them to successfully recover after cardiac damage, which could be used to repair heart tissues in humans.
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Researchers create blastocyst-like models from mouse cells
Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.
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Ten genes revealed to contribute to development of schizophrenia
Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.
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Researchers use new CRISPR method to alter specific bacteria strains
A study has demonstrated how to use CRISPR to deliver DNA to particular bacteria, which could be used as an alternative to antibiotics.
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NKAP gene mutation linked to rare developmental disease
A study has revealed that a mutation in the NKAP gene causes a rare syndrome, providing researchers with the potential to develop treatments for the condition.
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Three-dimensional structure of the genome replication machine discovered
New research provides insights into how cancers can arise when DNA polymerase delta is not functioning properly.
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Researchers discover new pathway to treat Ewing sarcoma
A study has demonstrated that blocking certain receptors in mice reduced Ewing sarcoma growth and metastasis, which could be used within future treatments.
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CRISPR-Cas9 variant shows high precision in gene editing
The newly identified variant could play a role in gene therapies that require high accuracy and precision.
