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DNA successfully cut and inserted using Class 1 CRISPR system
A new study has shown that a Class 1 CRISPR gene editing system can achieve functional DNA repairs in human cells with no prominent off-target effects.
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Drug Target Review – Issue 4 2019
This issue includes a discussion on the future of high-throughput screening through collaboration, an analysis of mass spectrometry as a structural biology tool and an exploration of the challenges of hit-to-lead when researching tropical diseases. Also in the issue are articles on immuno-oncology and assays.
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New method to analyse CRISPR editing developed
Researchers have announced the creation of a novel technique for screening CRISPR edits that allows scientists to identify unintended outcomes in the genome.
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Fruit fly model to study mitochondrial diseases developed
Researchers have created ‘three-parent flies' which can be used as a model to study mitochondrial diseases and screen potential drug compounds.
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Researchers find mutation in CUL3 gene responsible for autism
Scientists have shown that the mutated CUL3 gene, which is involved in the cell’s clearance of proteins, plays a role in the development of autism and schizophrenia in mice.
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Mucin 6 gene indicates predisposition to late-onset Alzheimer’s
Scientists have idenified that variation in a gene called Mucin 6 appears to indicate a tendency for acquiring Alzheimer’s disease.
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ELRIG Drug Discovery 2019: looking back to the future
On 5-6 November, ACC Liverpool hosted the ELRIG Drug Discovery event, which allowed R&D professionals to come together and discuss the latest industry developments.
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Modified CRISPR gene editing tool could improve therapies
New cell experiments show more effective genetic 'cuts' that could one day become the foundation of more effective gene therapies.
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Gene therapy for epilepsy shows promise in animal models
An AAV-delivered gene therapy has demonstrated success in animal models of temporal lobe epilepsy, so could be a therapeutic option for human patients.
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Genetic mutation in monkeys identified as cause of Bardet-Biedl Syndrome
A study has revealed that in rhesus monkeys, a genetic mutation could be the cause of Bardet-Biedl Syndrome, providing a way to study the disease and develop therapies.
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Researchers reveal how body repairs damaged DNA
A team has imaged the process that the body uses to stabilise DNA, which could be used to develop therapies for conditions such as cancer.
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New antiviral drug demonstrated to effectively treat influenza in models
A new antiviral drug has been reported in a study that researchers believe has high clinical potential as a next-generation influenza drug.
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Gene identified in zebrafish effective at repairing heart damage
Researchers have discovered a gene in zebrafish that enables them to successfully recover after cardiac damage, which could be used to repair heart tissues in humans.
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Researchers create blastocyst-like models from mouse cells
Mouse blastocyst-like structures called blastoids have been developed by a team which could be used to study early developmental diseases.
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Ten genes revealed to contribute to development of schizophrenia
Whole exome sequencing has been used by researchers to reveal 10 genes implicated in the development of schizophrenia.
