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Researchers use new CRISPR method to alter specific bacteria strains
A study has demonstrated how to use CRISPR to deliver DNA to particular bacteria, which could be used as an alternative to antibiotics.
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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NKAP gene mutation linked to rare developmental disease
A study has revealed that a mutation in the NKAP gene causes a rare syndrome, providing researchers with the potential to develop treatments for the condition.
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Three-dimensional structure of the genome replication machine discovered
New research provides insights into how cancers can arise when DNA polymerase delta is not functioning properly.
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Researchers discover new pathway to treat Ewing sarcoma
A study has demonstrated that blocking certain receptors in mice reduced Ewing sarcoma growth and metastasis, which could be used within future treatments.
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CRISPR-Cas9 variant shows high precision in gene editing
The newly identified variant could play a role in gene therapies that require high accuracy and precision.
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Researchers fail to replicate influential neuroimaging genetics study
These findings highlight the complexity of the relationship between genes and human brain function.
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Whole genome sequencing could be used to improve cancer treatments
Researchers have used whole genome sequencing to analyse breast cancers and reveal which are more responsive to treatments, which could improve the development of oncologic therapies.
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A biosynthetic pathway to identify new drug candidates
A new process for identifying and biosynthesising drug candidates has been discovered by researchers at the Carl R Woese Institute for Genomic Biology.
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Application note: High-throughput imaging and analysis of spheroids
High-throughput fluorescence imaging and analysis of spheroids - tips, tricks, and tools to efficiently grow, stain, image, and analyze 3D cell cultures
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New study shows insight into how cells maintain their identity
A new study shows the ways in which epigenetic mechanisms control the activity of genes and may have an impact on the future treatment of certain cancers.
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CRISPR used to treat Duchenne muscular dystrophy in mice
A study has shown that CRISPR can be used as a regenerative technique to treat Duchenne muscular dystrophy, which could be developed as a therapeutic option for humans.
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The elegant parallel of using CRISPR to understand disease mechanisms
CRISPR is the buzzword of the moment in the drug discovery industry – mainly due to its potential to correct disease-causing mutations. However, those using the technology need to be mindful that it is used responsibly, and possible risks are considered before use. Mark Behlke discusses the potential of CRISPR…
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Researchers explain how lymphoma cells metastasise to the brain
Chronic inflammatory processes in ageing brains lead to lymphoma cells that have entered the brain tissue being retained.
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Genomic medicine: cracking genomes to cure ‘incurable’ diseases
We are on the precipice of realising the true potential of genomics studies. Following completion of the Human Genome Project six years ago, huge strides have been made in understanding how the genome works, shedding light on disease pathogenesis and forging therapeutic efforts. In this article, Pushpanathan Muthuirulan explains how…
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Protein vital for enterovirus replication identified by study
Researchers have discovered a particular protein that is required for enterovirus replication and survival, presenting a therapeutic target.
