news
Immunotherapy and DNA damage repair combo could target lung cancer
Combination therapy with a CHK1 or PARP inhibitor, with an immune checkpoint inhibitor caused the regression of small cell lung cancer in all mice treated...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Reprogramming stem cells using the measles virus vector
A method has been developed to reprogram stem cells using the measles virus vector, cutting a four-step process to only one stage...
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PD-L1 assay specifically selects ideal patients for cancer treatment
An assay assessing the level of programmed death ligand 1 (PD-L1) could help to determine the method of treatment for lung cancer patients...
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Genomic approach to studying widespread malaria
Researchers have suggested that the most widespread human malaria parasite could be studied and possibly treated using genomics...
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Exploring the genome using transcription factors
Using transcription factors to explore and understand the genome could lead to the understanding of gene expression patterns...
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Genetic study reveals possible new routes to treating osteoarthritis
Scientists discover new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines...
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Catching lung cancer early using molecular profiling
Researchers have identified how they can differentiate between lesions in the airways that are benign and those that could become cancerous...
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CRISPR repurposed to develop better antibiotics
Mobile-CRISPRi could be used to guide gene expression, in turn control levels of proteins produced, enabling scientists to identify key antibiotic targets...
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UCLA researchers correct mutation causing IPEX
A stem cell therapy rectifying the FoxP3 gene has been developed to treat IPEX, and has virtually cleared symptoms of the condition in mice...
whitepaper
Whitepaper: The most important mouse in the world: the utility and applications of C57BL/6 models
Learn everything you need to know about the most widely-used mouse in biomedical research with this free whitepaper.
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Insights into controlling gene expression
A study has given insight into gene expression and could enable scientists to determine how certain RNAP inhibitors work within the body...
whitepaper
Whitepaper: Application of CRISPR/Cas to the generation of genetically engineered mice
Learn how the continued development of CRISPR gene editing technologies opens fresh possibilities for in vivo model design.
article
Omics-informed drug target discovery in combating emerging infectious diseases
The catastrophic consequences of ever-increasing rates of death from infectious diseases demands new experimental strategies for drug target selection and drug design. Over the last decade, the pharmaceutical industry has been wounded by several issues including failure of drug-development programmes, burgeoning cost of drug development, increasing regulatory control, lack of…
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Expert view: Challenges in drug discovery screening
The basic premise of drug discovery screening necessitates that the biological assays upon which it depends can be performed in a reproducible manner. In addition, the techniques employed must generate results that are biologically relevant and actionable.
news
Frizzled receptors could be drug targets for treating major diseases
Frizzled receptors, from the GPCR family, could soon be a target to treat numerous diseases such as cancer, fibrosis and CVD...
