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Cancer stem cells use normal genes in abnormal ways
Researchers have identified that MHC Class I-high, CDK1 high molecules may be at the heart of conditions including melanoma, pancreatic and colon cancers...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Micropeptide molecule restores heart function
A micropeptide molecule that reverses structural and functional changes in the heart could be a promising target for gene therapy...
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Laser-capture RNA seq technique connects Parkinson’s and psychiatric diseases
A comprehensive study reveals an expanding universe of 'darkest of the dark matter' RNAs in dopamine-producing cells in our brains...
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NLRP12 protein promotes healthy gut bacteria to curb obesity
Scientists have discovered that the anti-inflammatory protein NLRP12 normally helps protect mice against obesity and insulin resistance when they are fed a high-fat diet...
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Class of neurological disorders share 3D genome folding pattern
Researchers have found another common thread linking nearly all of the TNR expansion diseases...
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CRISPR used to deliver BChE into cells to protect from lethal cocaine doses
Researchers have described a novel approach that was able to stifle the desire for cocaine and to protect against an overdose...
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Expert view: The development of single‑cell genomics with Smart‑seq
Takara Bio has played a major role in the development of single-cell genomics with the launch of kits such as the automation-ready Smart-seq HT, with a simplified 4-steps protocol. In addition, to meetthe demand for using RNA-seq for degraded clinical samples, we have expanded our offering with a complete sequencing…
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Carving a pathway toward personalised cancer therapy
Individualised therapies that target the specific genetic features of tumours have the potential to transform cancer diagnosis, treatment and care. However, several challenges remain before these approaches can be widely used in the clinic.
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NGS: hunting mysterious ‘Dark Matter Genome’ towards rewriting the rules of human genetic diseases
Next generation sequencing (NGS) has revolutionised genomics research providing a wealth of genetic information of immense value to researchers. NGS technologies have been evolving over the last decade, leading to substantial improvement in understanding different biological systems from broader and deeper perspectives.1
whitepaper
Application Note: Full-length, single-cell RNA-seq with the SMARTer™ ICELL8® Single-Cell System
6 September 2018 | By Takara Bio
The data presented in this application note demonstrates how SMARTer ICELL8 Single-Cell System can be used to generate high-quality RNA-seq libraries that provide full-length transcript sequence information from hundreds of single cells in parallel...
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Expert view: Managing the complexity of finding new targets and drugging the undruggable
Assessing targets that are unable – or rather, extremely difficult – to reach pharmacologically, has prevented researchers from achieving desired clinical successes, most notably in the realm of cancer research. However, many advances are being made to shedlight on these difficult yet desirable target areas.
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CHAOS approach to antibiotic resistance
Researchers have developed a new CHAOS method to combat antibiotic resistance, using CRISPR DNA modification techniques...
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Scientists develop TSA-Seq technique for precise 3D mapping of human genome
Despite the human genome being first sequenced almost 20 years ago, researchers know comparatively little about how the genome is organised within cells. But a new TSA-Seq technique is changing that.
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NF-2 gene mutations make cells hyper-responsive to growth factor signalling
Researchers have determined one way that mutations in a gene involved in a rare, hereditary cancer syndrome lead to out-of-control cellular proliferation...
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CRISPR technique skips over portions of genes that can cause disease
Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...
