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Genomics

Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.

Expert view: Managing the complexity of finding new targets and drugging the undruggable

5 September 2018 | By Steven G Jarvis (Head of Pharma & Biotech Segment Strategy - MilliporeSigma)

Assessing targets that are unable – or rather, extremely difficult – to reach pharmacologically, has prevented researchers from achieving desired clinical successes, most notably in the realm of cancer research. However, many advances are being made to shedlight on these difficult yet desirable target areas.

news

CHAOS approach to antibiotic resistance

4 September 2018 | By Iqra Farooq (Drug Target Review)

Researchers have developed a new CHAOS method to combat antibiotic resistance, using CRISPR DNA modification techniques...

news

Scientists develop TSA-Seq technique for precise 3D mapping of human genome

29 August 2018 | By Drug Target Review

Despite the human genome being first sequenced almost 20 years ago, researchers know comparatively little about how the genome is organised within cells. But a new TSA-Seq technique is changing that.

news

NF-2 gene mutations make cells hyper-responsive to growth factor signalling

29 August 2018 | By Drug Target Review

Researchers have determined one way that mutations in a gene involved in a rare, hereditary cancer syndrome lead to out-of-control cellular proliferation...

news

CRISPR technique skips over portions of genes that can cause disease

17 August 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have adapted CRISPR to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building...

Pushpanathan Muthuirulan Harvard University, Cambridge

editorial-board

Pushpanathan Muthuirulan

13 August 2018 | By

Research Associate, Harvard University

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Reducing NOVA1 helps prevent tumour growth in lung cancer

8 August 2018 | By Dr Zara Kassam (Drug Target Review)

Researchers have identified a gene that when inhibited, reduced human non-small cell lung cancer tumours from growing...

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CRISPR-Cas9 used to correct sickle cell–causing mutation

7 August 2018 | By Dr Zara Kassam (Drug Target Review)

Genome editing using the CRISPR-Cas9 system has tremendous promise for therapeutic correction of genetic errors in human cells...

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Cas12a enzyme could make CRISPR gene-editing more effective

2 August 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists have identified an easy upgrade for the technology that would lead to more accurate gene editing...

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Susceptible genes for childhood nephrotic syndrome identified

30 July 2018 | By Drug Target Review

A specific haplotype was identified as having the highest risk of development, with another showing the lowest risk...

news

Researchers identify new arthritis severity gene

26 July 2018 | By Dr Zara Kassam (Drug Target Review)

A new gene associated with disease severity in models of rheumatoid arthritis has been identified by...

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Recessive disorder impairing eyesight has been discovered

24 July 2018 | By Drug Target Review

Blindness in children has been linked to a recessive genetic disorder caused by the MARK3 gene...

whitepaper

Whitepaper: A guide to achieving better insight with accurate data

17 July 2018 | By IDBS

In today’s modern world, data is everywhere. This eBook will guide you through the steps of how to achieve more with accurate data.

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3D map of CVD genetic interactions could aid future treatments

12 July 2018 | By Drug Target Review

A 3D map of genetic interactions in CVD could aid researchers investigating future treatments for heat attacks, heart failure and heart rhythm disorders.

whitepaper

Whitepaper: Opportunities in preclinical development

11 July 2018 | By IDBS

This whitepaper explains how you can find ways to optimise the holistic preclinical development process...

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Genomics