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PNA gene editing technique cures beta-thalassemia in utero
Researchers have for the first time used a gene editing technique to successfully cure a genetic condition in a mouse model...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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CRISPR technology can correct Alpha-1 antitrypsin deficiency
Groundbreaking research demonstrates proof-of-concept for using CRISPR-Cas9 genome editing technology to correct the gene mutation responsible for AAT deficiency...
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Genomics in drug development and safety testing; from target identification to genomic toxicology
In the annual report of the Chief Medical Officer, 1 Dame Sally Davies has declared that we are part of ‘generation genome’ – the era in which we reap the rewards of our advances in genomic technologies and improvements in our understanding of the whole genome in human health.
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Novel drug therapy partially restores hearing in mice
A small-molecule drug is one of the first to preserve hearing in a mouse model of an inherited form of progressive human deafness, report investigators at the University of Iowa, Iowa City, and the National Institutes of Health’s National Institute on Deafness and Other Communication Disorders (NIDCD).
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Administering hormones affects DNA
In an experiment with pigs, researchers have demonstrated for the first time that the administration of even extremely low doses of an endocrine disruptor - in this case, an endogenous oestrogen - leads to epigenetic changes in a pregnant sow’s DNA.
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C6 gene unlocks mysteries to our immunity
Researchers have identified a new gene that plays a critical role in regulating the body's immune response to infection and disease...
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Computational models provide genetic insight into atherosclerosis
Researchers find a gene in artery wall activated by lipids associated with coronary artery disease...
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TRAF7 gene mutations associated with multisystem disorders
A team of researchers have identified four different mutations in the gene TRAF7...
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NIH-funded study finds new evidence that viruses may play a role in Alzheimer’s disease
Analysis of large data sets from post-mortem brain samples of people with and without Alzheimer's disease has revealed new evidence that viral species, particularly herpesviruses, may have a role in Alzheimer’s disease biology.
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Molecular alterations provide insight into Huntington’s disease
Scientists have applied their high-throughput, multi-pronged approach to Huntington's disease, and uncovered the functional significance of various molecular changes...
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ATP1A3 gene mutations associated with infantile forms of schizophrenia
Scientists have identified novel genes associated with a specific form of schizophrenia the discovery will aid diagnosis and development of treatments...
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RNA-Seq assay can detect gene fusions in solid tumour cells
Using the RNA-Seq assay to detect gene fusions can improve the diagnosis and targeted treatment of solid tumors, reports The Journal of Molecular Diagnostics
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New evidence sheds light on how Parkinson’s disease may happen
Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism.
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The loss of CDK12 pinpoints to a new sub-type of prostate cancer
Tumours with alterations in the CDK12 gene were more responsive to immunotherapy, suggesting precision medicine approach...
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New epigenetic drug against Mantle Cell Lymphoma
A new study presents an epigenetic drug capable of slowing down cell growth in Mantle Cell Lymphoma (MCL)...
