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ATP1A3 gene mutations associated with infantile forms of schizophrenia
Scientists have identified novel genes associated with a specific form of schizophrenia the discovery will aid diagnosis and development of treatments...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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RNA-Seq assay can detect gene fusions in solid tumour cells
Using the RNA-Seq assay to detect gene fusions can improve the diagnosis and targeted treatment of solid tumors, reports The Journal of Molecular Diagnostics
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New evidence sheds light on how Parkinson’s disease may happen
Researchers at Baylor College of Medicine and Texas Children’s Hospital have identified unexpected new key players in the development of an early onset form of Parkinson’s disease called Parkinsonism.
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The loss of CDK12 pinpoints to a new sub-type of prostate cancer
Tumours with alterations in the CDK12 gene were more responsive to immunotherapy, suggesting precision medicine approach...
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New epigenetic drug against Mantle Cell Lymphoma
A new study presents an epigenetic drug capable of slowing down cell growth in Mantle Cell Lymphoma (MCL)...
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Artificial gene defect reveals target to fight genetic disease
Scientists have deployed a novel genetic screen to search for synthetic viable interactions on special lines of Fanconi Anaemia-defective cells...
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CRISPR-Cas9 tool could increase cancer risk
Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer...
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ANT1 mutation links bipolar disorder to mitochondrial disease
Researchers have reported that mitochondrial dysfunction affects the activity of serotonergic neurons in mice with mutations of ANT1...
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p53 gene prevents cancer development
Scientists have discovered how the most important gene in preventing human cancer, p53, is able to stop the development of lymphoma and potentially other types of cancer...
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Scientists create ‘genetic atlas’ of proteins in human blood
Researchers have created the first detailed genetic map of human proteins...
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Novel gene in red blood cells may help adult newts regenerate limbs
Japan-US research collaboration has found that red blood cells that express a novel gene may contribute to adult newt limb regeneration.
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Expert view: Discovering neuronal cell types
Target the genes that matter for efficient sequencing and analysis with custom-targeted gene panels.
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APOE4 gene variant linked to Alzheimer’s
A study reveals why people with the APOE4 gene have a higher risk of the disease...
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CRISPR approach could limit toxicity of CAR-T therapy in AML
New study uses CRISPR/Cas9 to make CD33 CAR T cells cancer-specific...
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Drug Target Review – Issue #2 2018
In this issue: the positive impact of genomics on drug discovery, development and deployment, the confluence of biology and technology, and Artificial Intelligence: harnessing the potential to drive progress in drug discovery promises much for phenotypic drug discovery