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X chromosome reactivation could treat Rett syndrome
Reactivation of the inactive X chromosome could lead to an increased expression of the healthy protein underlying the neurodevelopmental disorder...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Brainstem changes identified in Parkinson’s disease
Researchers have found that patients with Parkinson's disease have more errors in the mitochondrial DNA within the brainstem, leading to increased cell death...
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Chemical oscillators offer a new level of molecular control
Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit computation within molecular systems...
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Proteogenomics research – on the frontier of precision medicine
Proteogenomics is the systematic and comprehensive integration of proteomics with genomics and transcriptomics. Proteogenomics is opening new hallmarks in biomedical research. Recently, several studies have demonstrated the relevance of proteogenomics in cancer research. This article provides a brief review of the advantages of proteogenomics in precision medicine.
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Using 3D cell cultures to fight anti-cancer therapy resistance
An international team of researchers have developed 3D cell cultures in which genes can be specifically modified to improve the use of targeted anti-cancer drugs...
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Patient-derived neural progenitor cells as a drug discovery model for mitochondrial diseases
Mitochondrial DNA (mtDNA) mutations cause severe disorders that are untreatable and mostly affect the nervous system. The difficulty in funding therapies may also be explained by the lack of viable modelling systems...
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Application note: KingFisher sample purification system
Next generation sequencing sample preparation on the KingFisher platform...
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours
A study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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GDF6 gene associated with metastatic melanoma
Researchers have revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma...
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Tumour cell biology reveals characteristic that causes metastasis
A collaborative team of researchers in the US have uncovered characteristics of tumour cells that are linked to cancer metastasis.
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Lung tumours communicate with bones to progress disease
Scientists at Massachusetts General Hospital (MGH) have identified how a type of lung cancer co-opts a portion of the immune system via bone marrow to increase tumour progression.
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Tracking down genetic influences on brain disorders
Researchers have presented a systematic catalogue of specific variable locations in the genome that influence gene activity in the human hippocampus...
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CRISPR-dCas9 reveals surprising insight into breast cancer development
Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to become abnormal...
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DNA analysis incorporated into antenatal screening to test for chromosome disorders
Scientists have shown that it is possible to incorporate DNA analysis into antenatal screening for three serious chromosome disorders including Down's syndrome...