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Using 3D cell cultures to fight anti-cancer therapy resistance
An international team of researchers have developed 3D cell cultures in which genes can be specifically modified to improve the use of targeted anti-cancer drugs...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Patient-derived neural progenitor cells as a drug discovery model for mitochondrial diseases
Mitochondrial DNA (mtDNA) mutations cause severe disorders that are untreatable and mostly affect the nervous system. The difficulty in funding therapies may also be explained by the lack of viable modelling systems...
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Application note: KingFisher sample purification system
Next generation sequencing sample preparation on the KingFisher platform...
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Pancreatic cancer: specific protein promotes development of pancreatitis and tumours
A study has shown that disruption to cell autophagy is involved in the development of pancreatic cancer.
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GDF6 gene associated with metastatic melanoma
Researchers have revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma...
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Tumour cell biology reveals characteristic that causes metastasis
A collaborative team of researchers in the US have uncovered characteristics of tumour cells that are linked to cancer metastasis.
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Lung tumours communicate with bones to progress disease
Scientists at Massachusetts General Hospital (MGH) have identified how a type of lung cancer co-opts a portion of the immune system via bone marrow to increase tumour progression.
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Tracking down genetic influences on brain disorders
Researchers have presented a systematic catalogue of specific variable locations in the genome that influence gene activity in the human hippocampus...
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CRISPR-dCas9 reveals surprising insight into breast cancer development
Changing the epigenetic code of a single gene is enough to cause a healthy breast cell to become abnormal...
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DNA analysis incorporated into antenatal screening to test for chromosome disorders
Scientists have shown that it is possible to incorporate DNA analysis into antenatal screening for three serious chromosome disorders including Down's syndrome...
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Researchers produce the first draft cell atlas of the small intestine
By surveying gene expression, researchers have created a reference atlas for understanding the biology of inflammatory bowel disease and food allergies, among other conditions...
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SORLA protein protects against Alzheimer’s disease
Researchers have identified a new protective function for a brain protein genetically linked to Alzheimer's...
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Potential new treatment for Fragile X targets one gene to affect many
Inhibitors of chromatin remodelling proteins may be a potential treatment for Fragile X Syndrome...
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Sonic Hedgehog pathway identified as a target against medulloblastoma
Researchers raise hopes for developing a combination targeted therapy to treat medulloblastoma and other tumours...
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Prenatal exposure to BPA at low levels can affect gene expression
Prenatal exposure to BPA affects gene expression related to sexual differentiation and neurodevelopment in the developing brain...
