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Cell contacts in embryonic development determine cellular fate
Researchers have identified a positive feedback loop between the duration of cell-cell contacts and the specification of a cell's fate...
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Stem cell line offers expanded potential for research and treatments
Researchers have created Expanded Potential Stem Cells that have greater potential for embryonic development than current stem cell lines...
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Underlying genetic causes of congenital heart disease identified
Researchers have helped shed light on some of the underlying genetic causes of CHD as well as the long-term outlook for patients who carry these mutations...
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Microcapsules to enhance the efficiency of genome-editing
Researchers have found that polymer and hybrid silica-coated microcapsules are efficient in genome-editing...
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CRISPR-engineered cancer model to test therapeutics
A new technique for modelling leukaemia may aid drug discovery...
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CRISPR-Cas9 used to systematically inactivate genes in colorectal cancer
Researchers have used CRISPR-Cas9 to inactivate genes in human colorectal cancer cell lines -- one with normal KRAS gene and one with a mutant KRAS...
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MMP20 gene variants linked to high-risk childhood cancers
Paediatric researchers have identified common gene variants that raise the risk of an aggressive forms of childhood cancer...
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Genome editing reveals a role for OCT4 in human embryogenesis
Researchers have used genome editing technology to reveal the role of a key gene in human embryos in the first few days of development...
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GREB1L mutations associated with renal agenesis
A team of researchers has identified the mutated gene GREB1L is linked to renal agenesis...
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KDM4 inhibitor brings new hope for breast cancer
Scientists have shown that inhibiting the epigenetic regulator KDM4 may offer a potential novel treatment for breast cancer...
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New genetic cause discovered for photosensitive blood disorder
Researchers have uncovered a new genetic cause for erythropoietic protoporphyria...
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Novel genetic mutation discovered in Parkinson’s disease
Researchers have identified the first case of a patient with Parkinson's disease carrying a mutation in the ACMSD gene...
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How next-generation sequencing is opening the door for drug discovery
The Wellcome Trust Sanger Institute's Kim Judge explains how Next Generation Sequencing forms a crucial part of the scientist’s toolkit and makes a valuable contribution to the field of drug discovery...
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Calcilytics as potential novel therapeutic treatments to halt Alzheimer’s disease
Alzheimer’s disease (AD) is the most prevalent form of dementia.1 The common (>95% of cases) slow-developing form of the ailment is known as late-onset AD (LOAD) or sporadic AD (SAD). The rare (
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Genetic testing leads to response in MET fusion lung cancer
Researchers have identified a rare fusion involving the gene MET leading researchers to treat the cancer with a targeted therapy...
