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Reorienting drug discovery using spatial and temporal techniques
Dr Sheraz Gul examines how patient-driven imaging strategies can be utilised to aid the translation of initial research all the way into the clinic.
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Genomics
Genomics is the branch of molecular biology concerned with the structure, function, evolution, and mapping of genomes.
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Drug Target Review’s top content picks from 2022
In this article, Drug Target Review’s Izzy Wood and Ria Kakkad share some of the most ground-breaking moments from drug discovery this year.
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Genetic cause of ALS and dementia repaired by RNA-targeting strategy
US scientists have developed a potential medication for the genetic cause of ALS and dementia, that eliminates the mutated segments of RNA.
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Pattern of gene activity for ADHD is unlocked
US researchers identified that those with ADHD have differences in gene activity in the brain.
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New MACHETE technique developed to slice into cancer genome
Sloan Kettering Institute (SKI) researchers have developed a new machete technique to slice into the cancer genome and study copy number alterations.
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Five recent CRISPR drug target discoveries
This article highlights five of the latest findings revealed using CRISPR that could be used in the development or design of new therapies.
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Is the Nile rat the new animal model for diabetes research?
US researchers, using genome sequencing, put forward the Nile rat as the new model organism for diabetes research.
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Researchers make progress towards CRISPR-based microbiome editing
US researchers have engineered bacteriophages to deliver CRISPR-Cas payloads for targeted editing of a bacterium.
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Scientists discover the cause of Congenital Hyperinsulinism
A research team at the University of Exeter have found that the unexplored genomic control regions yield the key to finding causes of Congenital Hyperinsulinism.
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Monkeypox mutations cause virus to spread rapidly, evade drugs and vaccines
Researchers show how monkeypox mutations cause virus to replicate, spread faster.
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Pre-clinical model of appendiceal cancer developed
Researchers from the University of California have developed the first pre-clinical model of appendiceal cancer, containing all elements of the tumour.
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Researchers find that reduction in protein synthesis could lead to Feingold syndrome
The researchers used a zebrafish model to test mutations in Mycn, a gene which causes Feingold syndrome.
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Study offers new insights into genetic mutations in ASD
The study’s findings have important implications for better understanding the neurological basis for ASD and developing effective therapies for patients.
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Developing novel genome editing tools
In this Q&A, Dr Stephen Jones from Vilnius University Life Sciences Center discusses his work on the recent developments in genome editing tools at the university.
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3D map reveals DNA organisation within human retina cells
Scientists shed light on how genetic architecture in human retina cells determine gene expression, tissue-specific function, and disease phenotype in blinding diseases.