whitepaper
Application note: Real-time detection of Gs and Gi Signalling in living cells
Genetically-encoded biosensors from Montana Molecular allow for detection of GPCR signalling...
List view / Grid view
GPCRs
whitepaper
Application note: CRISPR/Cas9 genome-edited cells express nanoBRET-donor that monitors protein interaction and trafficking
In this application note, BMG Labtech discuss how the Bioluminescence resonance energy transfer (BRET) is a versatile tool to study interactions and trafficking in proteins.
news
Study changes long-held concepts of cell decoding
NIH scientists discover macromolecular complexes that could enable medication development...
whitepaper
Application note: Simultaneous detection of GPCR second messengers in living cells
Due to their role in signal transmission from the outside to the inside of a cell, G-protein coupled receptors are prominent drug targets...
whitepaper
Application note: Functional GPCR studies using AlphaScreen cAMP Detection Kit
In this application note, PerkinElmer demonstrates the ease and utility of the AlphaScreen® cAMP assay for detecting both agonist and antagonist-induced cAMP responses within cells.
webinar
The mast cell receptor MrgX2 and drug-induced anaphylaxis
10 May 2017 | By DiscoverX
The goal of this webinar is to illustrate how knowledge of MrgX2 activity across a panel of mammalian species can be integrated into drug development to influence choice of compound, species model and dosing regimen...
webinar
Simultaneous detection of GPCR second messengers in living cells
20 February 2017 | By BMG Labtech GmbH
Due to their role in signal transmission from the outside to the inside of a cell, G-protein coupled receptors (GPCRs) are prominent drug targets.
product
DiscoverX In Vitro Pharmacology Services – Simplify Your Drug Discovery Workflow
21 October 2016 | By DiscoverX Corporation
Monitoring cellular drug penetration and drug-target interaction enables assessment of compound efficacy and confirmation of mode of action...
product
Cisbio Bioassays GPCR – Kits and reagents to address the whole GPCR activation pathway
3 October 2016 | By Cisbio Bioassays
Cisbio Bioassays has supported GPCR investigation for many years regularly creating cutting edge assays and technologies suited to receptor characterization, compound screening and lead optimization...
article
High-throughput calcium flux assays: luminescent versus fluorescent readout
In vitro high-throughput cellular target-based assays are commonly used for hit identification targeting G-protein coupled receptors (GPCR). Agonist and antagonist identification of GPCRs often relies on the screening of large collections of chemicals using miniaturised in vitro cell-based functional assays. In the panel of assays, calcium mobilisation measured by aequorin…
news
Heptares and leadXpro to employ powerful new techniques for GPCR structure determination
29 June 2016 | By Victoria White, Digital Content Producer
Heptares Therapeutics and leadXpro are to employ powerful new approaches for the determination of high-resolution X-ray structures of GPCRs...
news
Heptares and Kymab enter antibody collaboration
18 April 2016 | By Victoria White, Digital Content Producer
Heptares and Kymab are to colllaborate to discover, develop and commercialise novel antibody therapeutics targeting a number of GPCRs...
product
DiscoverX GPCRscan® GPCR Profiling Services
22 February 2016 | By DiscoverX Corporation
GPCRscan is a functional cell-based GPCR assay panel for profiling drug compounds during drug discovery...
news
Heptares and Pfizer to focus on GPCR targets
30 November 2015 | By Victoria White
Heptares and Pfizer have announced they are to research and develop potential new medicines directed at up to 10 G protein-coupled receptor (GPCR) targets across multiple therapeutic areas...
article
Exploiting functional selectivity of GPCRs in drug development
The large family of pharmaceutical targets represented by G-protein coupled receptors (GPCRs) are usually involved in a number of intracellular effector pathways, leading to many cellular outcomes. In recent years it has been uncovered that different ligands of a given GPCR may engage the pathways selectively, in that ligands that…
