High-Throughput Screening (HTS)

Under the microscope: Choosing the best microplate reader

19 March 2018 | By Mark Wigglesworth (Director High-Throughput Screening - AstraZeneca)

Efficient microplate readers play an important role in effective hit molecule discovery. Mark Wigglesworth, of AstraZeneca, explains what he looks for in this technology.

High throughput flow cytometry for multifactorial evaluation of novel therapeutic candidates using an innovative in vitro immunooncology screening platform

19 March 2018 | By IntelliCyt Corporation

This recent webinar focused on the role of IntelliCyt’s iQue Screener PLUS platform as a high throughput suspension cell screening platform to facilitate simultaneous assessment of multiple parameters, while using minimal sample volumes.

Lab Automation In-Depth Focus 2018

16 March 2018 | By Drug Target Review

In this issue: how lab automation has accelerated pharmaceutical research by simplifying operations, reducing manual tasks and increasing the efficiency, quality and reproducibility of results.

Assays In-Depth Focus 2018

14 March 2018 | By Drug Target Review

In this In-Depth Focus: high throughput strategies for antibody library screening, and the latest in vitro 3D cell and tissue culture model systems in HTS.

GAPSA reveals new HIV targets

28 February 2018 | By Drug Target Review

Researchers have developed the first-ever high-throughput, genome-scale imaging-based approach to investigate protein stability...

Charles River Laboratories makes investments in high-throughput screening infrastructure

5 February 2018 | By Charles River Laboratories

Signs collaboration agreement with AstraZeneca to offer state-of-the-art technology to clients.

BMG LABTECH Australia celebrates 20 years of customer service excellence in the APAC region

16 January 2018 | By BMG Labtech GmbH

This year, BMG LABTECH’s Australian office celebrates 20 years of innovation and steady growth. The office was established in January 1998 to support Australia and the APAC region, offering excellent sales and customer service for BMG LABTECH’s wide range of dedicated and multi-mode microplate readers.

High throughput flow cytometry for multifactorial evaluation of novel therapeutic candidates using an innovative In vitro immuno-oncology screening platform

4 January 2018 | By IntelliCyt Corporation

In this webinar, speakers discussed how the IntelliCyt iQue Screener Plus platform is being utilised to deliver rich datasets for compound screening, target validation and is how it is transforming immuno-oncology.

Application note: High throughput quantitation of cytokine biomarkers using LANCE Ultra TR-FRET assays

4 January 2018 | By Jen Carlstrom (PerkinElmer), Roger Bosse (PerkinElmer), Stephen Hurt (PerkinElmer)

In this application note, PerkinElmer demonstrates the sensitivity, robust performance, and HTS suitability of the LANCE Ultra cytokine biomarker kits.

Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology

3 January 2018 | By Daniel Cardillo (PerkinElmer), Dawn Nida (PerkinElmer), Hong Cao (PerkinElmer), Jen Carlstrom (PerkinElmer)

In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.

BMG Labtech GmbH

Expert view: Optimising the hit-to-lead workflow

13 December 2017 | By Dr. Paul Wylie (Head of Applications at TTP Labtech)

Hits identified in high-throughput screens are evaluated within the hit-to-lead phase of drug discovery, where they undergo an iterative optimisation process employing a variety of techniques to identify promising lead compounds to move forward to the lead optimisation phase.

Machine learning approaches as tools to accelerate drug discovery

12 December 2017 | By Alexey Zakharov, Anton Simeonov

Computational methods based on machine learning approaches are being introduced increasingly widely to screen the large number of molecules that have never participated in the drug discovery process, but which might have significant drug development potential. This article considers the latest advances in machine learning as applied to drug discovery...

Expert view: Addressing the big challenges in drug screening

12 December 2017 | By Joesph Zock (Product Managemenr at IntelliCyt)

One of the biggest challenges facing drug discovery across all therapeutic modalities (small molecule, biologics, and cellular) remains the balance between physiological relevance and throughput.

Hit To Lead In-Depth Focus 2017

6 December 2017 | By Drug Target Review

In this In-Depth Focus we look at a pragmatic approach to hit validation following biochemical high-throughput screening as well as identification of hits and leads for human African trypanosomiasis.