product
DiscoverX HitHunter® cAMP Assays
21 December 2016 | By DiscoverX Corporations
Optimized Assays for a Multitude of GPCR Applications...
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High-Throughput Screening (HTS)
article
Screening In-Depth Focus 2016
In this Screening In-Depth Focus, scientists from the Assay Development and Screening Platform of Helmholtz Zentrum München provide an overview of different high-throughput screening (HTS)-applicable assay types that can be applied to drug discovery campaigns. Plus an interview with Lee Babiss, CEO of drug discovery firm X-Rx, on the benefits…
article
HTS assays for the identification of small-molecule inhibitors of deubiquitinating enzymes
The covalent modification of proteins by the attachment of ubiquitin (ubiquitination) is best known for its function to label proteins for proteasomal degradation. However, ubiquitination also plays non-proteasomal roles during signal transduction, DNA repair and protein sorting...
whitepaper
App note: Evaluation of RNA isolation efficiency of Pall AcroPrep™ Advance 96-Well Long Tip Filter Plate for Nucleic Acid Binding
In this application note, Pall Laboratory evaluate the performance of the Pall AcroPrep Advance 96-Well Filter Plates for Nucleic Acid Binding (Pall NAB plate), which contain a silica-based quartz glass fiber media for the isolation of total RNA...
whitepaper
App note: AcroPrep™ Advance 96-well Long Tip Filter Plate for Nucleic Acid Binding for high-throughput purification of plasmid DNA
In this application note, Pall Laboratory describe the use of AcroPrep Advance 96-well Long Tip Filter Plate for Nucleic Acid Binding...
product
Cisbio Bioassays EPIgeneous™ biochemical and cellular assays
4 October 2016 | By Cisbio
Rapid advancements have been made in understanding the key role epigenetic modifications play in regulating cell activity and their implications on cell health and disease progression...
webinar
Use of IntelliCyt’s iQue Screener for high-throughput screening of small molecules, CRISPRs and stem cells
29 September 2016 | By Intellicyt
This webinar highlights the use of the iQue Screener for high-throughput screening of stem cells, small molecules and CRISPR functional screening, presented by David Sykes, M.D., Ph.D., Researcher from Massachusetts General Hospital and Thibault Jonckheere, CEO and Séverine Giltaire, Senior Scientist from ImmunXperts...
article
High-throughput calcium flux assays: luminescent versus fluorescent readout
In vitro high-throughput cellular target-based assays are commonly used for hit identification targeting G-protein coupled receptors (GPCR). Agonist and antagonist identification of GPCRs often relies on the screening of large collections of chemicals using miniaturised in vitro cell-based functional assays. In the panel of assays, calcium mobilisation measured by aequorin…
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Hit-to-lead in drug discovery
Starting in the 1970s, the drug discovery research process changed dramatically. Our understanding of biological targets and pathways grew and the largely empirical and target agnostic in vivo pharmacology approach was replaced with target-centric methods...
news
TB Alliance and Takeda advance programme to find new TB treatments
22 June 2016 | By Victoria White, Digital Content Producer
TB Alliance and Takeda are to explore hits generated from a high-throughput screening programme conducted to find novel compounds to treat tuberculosis...
webinar
High-throughput Screening: An Insider’s Guide to Outsourcing
14 June 2016 | By Charles River
This webinar reviews successful high throughput screening programs to provide an overview of the process from assay development to final data package...
news
Novel anti-diabetic drugs that can be controlled with light
11 April 2016 | By Victoria White, Digital Content Producer
New research could pave the way for a new generation of anti-diabetic drugs that are activated by the presence of either blue or ultra-violet light...
product
Product Hub: Advanced high-throughput screening in a microplate reader
17 March 2016 | By BMG Labtech
BMG LABTECH has developed the new reference multi-mode microplate PHERAstar® FSX reader for HTS applications. This reader was specifically conceived for the fastest read times, the best sensitivity and unmatched flexibility in all plate formats up to 3456 wells...
news
Amping antimicrobial discovery with high-throughput screening
16 March 2016 | By Victoria White
Researchers from NIST have shown that high-throughput screening can dramatically speed up the challenging task of antimicrobial discovery...