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High-throughput method used to identify cancer drug candidates
A study using high-throughput screening has revealed some promising compounds that could be used in future cancer treatments.
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Drug Target Review – Issue 3 2019
This issue includes an investigation into utilising recombinant antibodies for research, a highlight on protein design using computational methods and an examination of the advances in genomic medicine. Also in the issue are articles on next generation sequencing and upstream bioprocessing.
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Compound promotes healing of myelin in nervous system disorders
A compound that promotes the rebuilding of the protective sheath around nerve cells damaged in multiple sclerosis has been developed.
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Potential sepsis prevention in burn patients found with novel approach
A new study has demonstrated the possibility of treating antibiotic-resistant Pseudomonas aeruginosa which causes sepsis in burn patients.
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The promise and pitfalls of serial femtosecond X-ray crystallography
A report from scientists at the Moscow Institute of Physics and Technology highlights the advantages and disadvantages of serial femtosecond X-ray crystallography. This article investigates the review, focusing on its role in drug development.
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Unhealthy gut microbiomes in mice remodelled into more healthy ones
Scientists have shown that there are molecules to remodel the gut microbiome and turn an unhealthful gut into a more healthful one for the first time.
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Researchers image structure of cancer metastasis target
The structure of a key receptor involved in tumour metastasis has been imaged in a study, providing opportunities to develop cancer treatments.
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Cyclisation reaction enables screening of macrocyclic compounds libraries
Libraries of more than 9,000 macrocyclic molecules below 1 KDa have been generated, small enough to cross cell membranes and reach targets.
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Optofluidic chip platform developed for single molecule analysis
A new platform has enabled an unprecedented level of control over individual molecules and particles on a chip for high-throughput analysis.
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Experimental treatment slows prion disease
A new experiment has not only slowed the progression of the prion disease, scrapie, it also extended the lives of prion-infected mice
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Molecular Devices introduces the FLIPR® Penta system
Molecular Devices, LLC, today announced the launch of the next generation of its FLIPR® Penta High-Throughput Cellular Screening System.
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New therapy discovered to treat acute lymphoblastic leukaemia
Researchers have discovered a new combination therapy to treat drug-resistant acute lymphoblastic leukaemia, tested in pre-clinical trials.
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Chemical synthesis and biological screening combined on chip
Researchers have developed a chip which facilitates and accelerates active substance production, characterisation and biological effectiveness.
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Researchers take a leap forward for new anti-inflammatory drugs
Treatments for chronic inflammatory diseases are one step closer as a new study discovers a way to stop inflammation in its tracks.
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