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Potential drug targets found by muting large silent genes
Streptomyces bacteria has been used to identify compounds that could lead to the production of drugs to treat various conditions...
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Webinar highlights: Harmonising drug-target binding data analytics on a single platform
Harmonising drug-target binding data analytics looks at building a single, integrated software platform for a future pharma research and development digital ecosystem. This webinar, sponsored by PerkinElmer, outlined the fundamentals of a design process where an experimental analytics data workflow was integrated into a more seamlessly interactive digital platform.
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PAINS management: an open source model to eliminate nuisance compounds
High-throughput screening (HTS) technologies have enabled the routine testing of millions of compounds towards the identification of novel ‘hit’ molecules for therapeutic targets. Oftentimes in this drug discovery process, however, compounds that show promising activity in primary screens show no activity during subsequent hit qualification or progression efforts.
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Hit-to-Lead In-Depth Focus 2018
This In-Depth Focus examines our understanding of the comprehensive and complex innate immune system, to develop novel treatments and an open source model to eliminate nuisance compounds
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Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Stimulating fibroblasts can trigger hair growth in wound healing
Stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing...
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Drug Target Review – Issue 4 2018
In this issue: Omics-informed drug target discovery in combating emerging infectious diseases, measuring intracellular ATP levels to access compound-mediated cellular toxicity, and turning organoids into physiologically relevant high-content assays for drug discovery.
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War On Cancer 2018: targeted therapies in oncology
War On Cancer 2018 discussed how cancer treatments have evolved over the last few decades, and looked at the future of cancer therapies...
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PCSK9 inhibitors to treat high cholesterol
Low-density lipoprotein cholesterol could be treated by using synthetic DNA-encoded monoclonal antibodies to inhibit PCSK9...
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Anti-inflammatory bacterial protein discovered in zebrafish
An anti-inflammatory bacterial protein discovered in zebrafish could lead to the discovery of anti-inflammatory proteins within humans...
webinar
Harmonising drug-target binding data analytics on a single platform
6 November 2018 | By PerkinElmer
This webinar outlined the fundamentals of a design process where an experimental analytics data workflow is being integrated into a more seamlessly interactive platform...
news
MDM2 inhibitors as a possible treatment for uveitis
MDM2 inhibitors could be used as a treatment for uveitis, a disease affecting the middle layer of the eye, causing inflammation and redness...
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Antibacterial compounds focusing on LsrK kinase
Researchers at the University of Eastern Finland have developed antibacterial compounds based on the action of LsrK kinase...
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SERDs molecules could spur a new class of drugs for breast cancer
Stevens researchers design and develop a new class of molecules for breast cancer therapy...
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Six compounds identified from 70,000 to help eradicate malaria
Researchers from Imperial College London have identified 6 compounds from almost 70,000 that could help to eradicate malaria...