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Researchers reveal structure of mega-enzymes from bacteria and fungi
Researchers have uncovered the structure of nonribosomal peptide synthetases (NRPSs), an important ingredient in drug production.
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Imaging
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Self-aligning smart microscope achieves unprecedented resolution
The developers of the ultra-precise single-molecule microscope demonstrated it can resolve interactions between molecules within living cells and is compatible with existing microscopes.
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New label-free microscopy method enables imaging inside living cells
By combining quantitative phase microscopy and molecular vibrational imaging, researchers have created a new label-free microscopy technique.
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Nanobodies developed to image COVID-19 Spike protein
Researchers in the UK have selected nanobodies that bind with high affinity to the Spike protein on the COVID-19 coronavirus, enabling stabilisation for imaging.
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VP3 protein: revealing the structure of a potential rotavirus drug target
Researchers hope that by revealing the rotavirus VP3 protein structure and mRNA capping functions, novel antivirals could be designed to prevent or combat rotavirus infections.
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Novel 3D imaging technology could improve fluorescence microscopy
A new technique called Coded Light-sheet Array Microscopy (CLAM) has been developed by researchers to improve 3D imaging of living specimens.
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Label-free array system market to be worth $1,600 million by 2025, study finds
The global label-free array system market will grow at a compound annual growth rate of 7.44 percent in the forecast period, says new research.
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New imaging technique developed to study fungi
German researchers have developed a novel imaging technique called expansion microscopy (ExM) to investigate fungi samples.
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Video: Increased reproducibility with KingFisher™ instruments
ESHG 2019 Conference Presentation: Using KingFisher™ to increase reproducibility in new applications using challenging samples.
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Nanoparticles used to kill endometriosis lesions in animal models
Using dye-loaded nanoparticles which can heat up with near-infrared light, researchers have been able to image and treat endometriosis in animal models.
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Organoids for the development of drugs and diagnostics for NASH
Organoids at different stages of non-alcoholic steatohepatitis (NASH) progression have been created to help in drug design and identification of diagnostic biomarkers.
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Novel tuberculosis transport protein could be target of new treatments
Cryogenic electron microscopy revealed that the vitamin B12 transporter on Mycobacterium tuberculosis acts like a non-selective sluice, transporting both the vitamin and antibiotics.
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Scientists reveal structure of norovirus using cryo-EM
Researchers captured 13,000 images of a mouse norovirus using an electron microscope and compiled the images to reveal the structure of the virus.
whitepaper
ebook: Habitat for disease – disrupting the tumour micro-environment
No tumour prevails on its own. Rather, every tumour needs a community to thrive.
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Imaging technique allows study of early stage Alzheimer’s disease
Scientists used optical photothermal spectroscopy (O-PTIR) to image murine neurons affected by early stage Alzheimer’s disease, providing insight into the progression of the disease.