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Team creates new nanoplatform for delivering drugs into T cells
Researchers have developed a pH-sensitive drug delivery system in T cells using C-terminal dendrimers with Phenylalanine.
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Immuno-oncology therapeutics
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Research reveals CDH17 represents a new approach to treat solid cancers
Pre-clinical research has found that CAR T cells can suppress gastrointestinal cancer cells without causing harm to healthy tissues.
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CAR T-cell implant effective at attacking cancer in pre-clinical study
Researchers have created an implantable biotechnology that produces and releases CAR T cells for attacking cancerous tumours.
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New potential therapy developed in response to bladder cancer
Research in mice has shown that adding anti-inflammatory medication to immunotherapy and standard chemotherapy drugs may provide long-term suppression of aggressive bladder tumour growth.
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Promising potential therapeutic strategy against pancreatic cancer developed
Scientists have discovered a new strategy that can make pancreatic tumours visible to the immune systems of mice and vulnerable to immune attack.
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Enhanced way to generate effective personalised cancer vaccines revealed in study
Scientists have created a pipeline for identifying, prioritising and evaluating potential tumour antigens for personalised cancer vaccines.
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Pre-clinical study shows significant increase in effectiveness of breast cancer immunotherapy
Scientists have discovered the essential role of a ligand-dependent corepressor to potentially enable cancer cells to present tumour antigens on their surfaces.
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Study provides possible answers to why immunotherapy for ovarian cancers often fails
New research has discovered metabolic mechanisms that contribute to how ovarian cancer escapes from immune attack and how combination therapies can exploit these pathways to improve ovarian cancer treatment.
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Enzyme revealed as promising new target for cancer immunotherapies
A new study has highlighted an enzyme called ART1 as a promising target for immunity-boosting cancer treatments.
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New findings could improve personalised cancer immunotherapies
A new study has highlighted that gene expression profiling could enable rapid identification of anti-tumour immune cells for personalised immunotherapy.
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Medicenna’s MDNA11 a promising alternative to checkpoint inhibitors
Medicenna's IL-2 super-agonist, MDNA11, successfully induced antitumour cells in animal models, a pre-clinical study has revealed.
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STING-activating drugs could customise cancer treatments
An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.
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Stem-like T cells could improve immunotherapy treatments
Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.
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High-intensity focused ultrasound therapy moves closer to the clinic
Researchers are investigating how high-intensity focused ultrasound (HIFU) can work on a cellular level to treat a range of cancers.
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Triple drug combination shows promise for pancreatic cancer treatment
MIT researchers have shown that a combination of three drugs can eliminate pancreatic tumours in mice, possibly leading to new therapies.
