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Immunogenicity

Scientists in lab coat working with test tubes

Toxicology transformed: Why accuracy now leads the way

11 December 2024 | By Bhupesh D. Sompura – Method Development Team Lead at Sannova Analytical

Regulatory changes are reshaping toxicology, with precision now at the forefront. We explore how accurate target analysis is transforming drug development, particularly for biotherapeutics.

atrial fibrillation.Human,Circulatory,System,Heart,Anatomy.,3d

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Targeting immune cells may help treat atrial fibrillation

20 July 2023 | By Izzy Wood (Drug Target Review)

New MGH study finds that macrophages and macrophage-produced proteins contribute to heartbeat irregularities, thus targeting these cells can aid atrial fibrillation treatment.

news

Multifaceted flu vaccine demonstrates wider protection

2 February 2022 | By Mandy Parrett (Drug Target Review)

Scientists at Georgia State University have developed an intranasal influenza vaccine using a new combination of nanoparticles for improved defence against flu strains.

Brain highlighted in orange surrounded my COVID-19 cells

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Discovery unveils genetic risk factor shared by Alzheimer’s and COVID-19

12 October 2021 | By Anna Begley (Drug Target Review)

Scientists have identified the OAS1 gene as a risk factor for both Alzheimer's disease and COVID-19, suggesting potential drug targets.

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Artificial intelligence may reveal how microbiome affects vaccine response

6 August 2021 | By Anna Begley (Drug Target Review)

Researchers have been using artificial intelligence to study how the microbiome interacts with the human system to improve vaccine response.

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Novel DNA-based COVID-19 vaccines induce immune responses in mice

5 February 2021 | By Hannah Balfour (Drug Target Review)

The DREP-S vaccine candidate was found to be the most potent of the two investigational vaccine prototypes, eliciting high titers of SARS-CoV-2 neutralising antibodies after a single dose.

Black and red capsules in a pile with top one labelled 'COVID-19' in white writing - idea of a tablet/pill COVVID-19 vaccine

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COVID-19 vaccine tablet significantly reduces viral load in hamsters

17 November 2020 | By Hannah Balfour (Drug Target Review)

Hamster challenge study results suggests the oral COVID-19 vaccine induces a robust immune response, protecting the animals from infection.

mosquito on human skin, the vector for transporting leishmania parasite between hosts

article

Flow cytometry in neglected tropical diseases – a focus on leishmaniasis

10 September 2020 | By Professor Paul Kaye (University of York)

The World Health Organization (WHO) identifies leishmaniasis as a neglected tropical disease for which new treatments are vitally needed. Leishmaniasis primarily affects people in South America, East Africa and Asia, especially those weakened by malnutrition and poverty. To help those with this disfiguring and potentially life-threatening parasitic disease, the European…

article

Neoantigens: presenting new vaccine opportunities in immuno-oncology

4 June 2020 | By Nikki Withers (Drug Target Review)

Neoantigens have gained much interest in recent years, mainly due to their ability to elicit a strong, specific immune response. Nikki Withers spoke to two immunology experts to explore the progress being made and assess what remains challenging for cancer investigators working on these transformational therapies.

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Researchers develop vaccine with potential to treat pancreatic cancer

27 November 2019 | By Victoria Rees (Drug Target Review)

A study has demonstrated that a novel vaccine design for pancreatic cancer has been successful in mice, doubling survival time.

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Application note: A Simoa™ Bridging Assay for Anti Drug Antibody Detection

26 November 2019 | By Quanterix

Therapeutic drugs based on biological materials (antibodies, hormones, cytokines, enzymes, fusion proteins) may have the ability to elicit an immune response in the host.

news

Research reveals calcium signalling pathway in T cells

9 October 2019 | By Victoria Rees (Drug Target Review)

A study has uncovered the mechanism behind calcium entry and exit into T cells, which could be used in development of autoimmune disease treatments.

whitepaper

Application note: Detection of anti-drug antibody (ADA) using single molecule counting (SMC^TM) technology

11 June 2019 | By Merck

All biological therapeutics have the potential to induce an immunemediated response ranging from benign to severe adverse effects.

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Researchers uncover origin of virus-fighting plasma B cells

19 April 2018 | By Drug Target Review

A group of researchers have discovered an important mechanism that governs how B cells are chosen to become plasma cells...

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HIC1 protein may protect against intestinal disease

26 February 2018 | By Dr Zara Kassam (Drug Target Review)

Scientists find molecular link between Vitamin A derivative and mouse intestinal health...

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Immunogenicity