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Faulty gene could be responsible for some Crohn’s disease cases
Interaction between MDR1 gene and TH17 immune cells in the ileum could hold the key to Crohn's disease in some instances.
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Immunogenicity
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Scientists jump hurdle in HIV vaccine design
Scientists at The Scripps Research Institute (TSRI) have made another important advance in HIV vaccine design.
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An interview with Uwe Gudat from Merck Serono, speaker at the 4th Annual Biosimilars & Biobetters Congress, 18-19 April 2016, London
13 January 2016 | By Oxford Global
In anticipation of our 4th Annual Biosimilars & Biobetters Congress, we spoke to one our expert speakers about the some of the key issues in the industry...
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Immunogenicity: anticipating and avoiding issues for biopharmaceutical development
All biopharmaceutical products are associated with an intrinsic potential to induce immune responses in treated subjects. Regulatory agencies expect sponsors to evaluate and mitigate these risks during product development, applying a strategy that addresses product- and patient-related factors. Overall, understanding and controlling immunogenicity-related risks are attainable objectives, and approvability should…
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Selecta Biosciences initiates Phase 1 clinical study of SEL-212 in gout
10 June 2015 | By Victoria White
Selecta Biosciences has initiated a Phase 1 study to assess the safety, pharmacodynamic profile, and immunogenicity of pegsiticase, a component of SEL-212...
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Developing antibody therapeutics
Monoclonal antibodies have come of age as therapeutics; there are now more than 30 antibodies on the market and over 200 in clinical trials. The attractions of therapeutic antibodies lie not only in their potential to make potent drugs but also their relative low risk in comparison to small molecule…
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Inovio partners with GeneOne Life Science for MERS vaccine clinical development
3 June 2015 | By Victoria White
Inovio has said it will advance its DNA vaccine for MERS into a Phase I clinical trial in healthy volunteers in a collaboration with GeneOne Life Science...