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Video: Anti-Idiotypic antibodies for development of CAR T cell therapies
Interview with Michael Schwenkert, Bio-Rad Laboratories, on best practices for the characterisation and quality control of anti-idiotypic antibodies for bioanalysis.
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Immunology
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Biodegradable gel boosts immune system’s attack on several cancers in mice
A new biodegradable gel can release drugs and special antibodies that simultaneously deplete macrophages from the surgical site and activate T cells.
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Viewing disease through the lens of memory B cells: improving cancer and infectious disease treatment
Looking at disease through a patient’s memory B cells can reveal vulnerabilities within pathogens. In this article, Dr Purnanand Sarma, President and Chief Executive Officer of Immunome, explores how advancements in memory B-cell antibody-based treatments will improve our understanding of how these cells can aid in fighting cancer and other diseases.
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Bulletin: Utilising the multiparameter capability of the Ze5 Cell Analyser to monitor T cell exhaustion and effects of immunotherapy
Read this bulletin to learn about a Bio-Rad study where they developed and tested a 16-parameter flow cytometry panel applicable to the interrogation of a range of biologically relevant markers of T cell activation.
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Two-faced protein both inhibits and activates B cell receptor signalling
New research could point towards a way to restore immune function in patients with immune disorders involving B cell signalling deficiencies.
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Potential origins of scleroderma highlighted in new study
Researchers at the Weizmann Institute of Science have shown that fibroblasts may be a factor in the origin of scleroderma.
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Study highlights the essential role of dendritic cells in immunotherapy
Researchers have discovered how immune system dendritic cells are key to maintaining and regulating response to immunotherapy.
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Novel systems for realising the promise of DNA vaccines and enabling the next generation of genetic medicines
Dr John Lewis, CEO of Entos Pharmaceuticals, outlines how an innovative proteolipid platform could enable a new class of DNA-based vaccines in this article.
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Drug Target Review Immuno-oncology ebook 2022
Included in this ebook are articles on how to develop more effective CAR T cells by modifying the CAR design and why recent findings about ferroptosis in cancer cells could enhance immunotherapies.
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Guide: How efficient is your lab? – Try this calculator
Do you know how much time your lab spends on pipetting tasks daily? If not you can easily find out. Just answer four simple questions, then Flow Robotics' calculator can give you a full report on how your lab is doing in minutes.
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New findings may lead to cardiovascular disease treatment
New research has found that immune cells produce a chemical messenger that prevents heart disease–related inflammation
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Novel genome-wide approach to engineer more effective immunotherapy
Scientists have developed a genetic screening platform to identify genes that can enhance immune cells to make them more persistent and increase their ability to eradicate tumour cells.
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Drug Target Review Vaccine Development ebook 2022
In this ebook, find articles on vaccination strategies for neurodegenerative diseases and the benefits of mRNA vaccine platforms against latent viruses.
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Team creates new nanoplatform for delivering drugs into T cells
Researchers have developed a pH-sensitive drug delivery system in T cells using C-terminal dendrimers with Phenylalanine.
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Research reveals CDH17 represents a new approach to treat solid cancers
Pre-clinical research has found that CAR T cells can suppress gastrointestinal cancer cells without causing harm to healthy tissues.