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Immune cells could be key to tuberculosis treatment, study finds
Researchers have found that certain immune cells aid in fighting tuberculosis bacteria, providing a new drug target.
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Immunology
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Creating blood vessels on demand
A new study shows that stable angiogenesis can be achieved by simply injecting a hydrogel with mechanical properties resembling that of a blood clot...
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FGL2 protein may be an effective target for GBM
Researchers have discovered an immune regulator that appears to dictate glioblastoma progression by shutting down immune surveillance...
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Stopping inflammation using a molecular switch
A component in the ubiquitin system has been described as being able to deactivate the innante immune system and could help to prevent immune conditions...
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Engineered T-cells promote acceptance of organs after transplant
Controlling coronin 1 in T-cells could lead to the immune system not attacking transplanted organs, but still fighting other infections...
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Oral squamous cell carcinoma prognostic signature identified
Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...
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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
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Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Vaccine signatures point to a better understanding of infectious diseases
Researchers have developed a comprehensive way to evaluate how immune responses of humanised mice measure up to actual humans...
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Stimulating fibroblasts can trigger hair growth in wound healing
Stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing...
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Majority of HIV persistence during ART due to infected cell proliferation
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure...
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Scientists test new anti-PD-L1 cancer vaccine against melanoma
An experimental cancer vaccine that boosts the immune system's ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumours, scientists have reported...
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Tethered antibodies may prevent influenza virus infections
Investigational therapeutic candidate made with four antibodies tethered together shows promise against influenza A and B...
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Nonresponsive NK cells directly impact malaria severity
The failure of natural killer cells (NK cells) to respond to infection explains why malaria causes a worse reaction in some patients than others.
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Alpaca immune system reveals a potential treatment for cancer
Researchers have identified camelid nanobodies that are able to block EGF, a protein that is abundant in tumour cells...