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Stopping inflammation using a molecular switch
A component in the ubiquitin system has been described as being able to deactivate the innante immune system and could help to prevent immune conditions...
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Immunology
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Engineered T-cells promote acceptance of organs after transplant
Controlling coronin 1 in T-cells could lead to the immune system not attacking transplanted organs, but still fighting other infections...
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Oral squamous cell carcinoma prognostic signature identified
Discovery based on analysis of tissue and saliva samples from oral cancer patients shows a correlation between a signature comprising three peptides and the presence of lymph node metastasis...
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T-cells engineered to recognise tumours expressing the CD30 protein marker
Researchers have genetically engineered immune cells to recognise and fight Hodgkin and non-Hodgkin lymphoma cells...
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Targeting innate immunity to treat disease: potential therapeutic applications
Despite being one of the more ancient aspects of immunity, therapeutic modulation of the innate immune system has rarely been attempted. Innate immunity is intrinsically linked to the generation of inflammation – necessary for signalling to the adaptive immune system but often self-perpetuating and over-exaggerated, leading to deleterious effects, including…
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Vaccine signatures point to a better understanding of infectious diseases
Researchers have developed a comprehensive way to evaluate how immune responses of humanised mice measure up to actual humans...
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Stimulating fibroblasts can trigger hair growth in wound healing
Stimulating fibroblasts through the sonic hedgehog pathway can trigger hair growth not previously seen in wound healing...
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Majority of HIV persistence during ART due to infected cell proliferation
Study confirms biological mechanism responsible for latent HIV reservoirs; suggests strategies for a functional HIV cure...
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Scientists test new anti-PD-L1 cancer vaccine against melanoma
An experimental cancer vaccine that boosts the immune system's ability to fight cancers could work in tandem with other cancer therapies to fight aggressive tumours, scientists have reported...
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Tethered antibodies may prevent influenza virus infections
Investigational therapeutic candidate made with four antibodies tethered together shows promise against influenza A and B...
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Nonresponsive NK cells directly impact malaria severity
The failure of natural killer cells (NK cells) to respond to infection explains why malaria causes a worse reaction in some patients than others.
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Alpaca immune system reveals a potential treatment for cancer
Researchers have identified camelid nanobodies that are able to block EGF, a protein that is abundant in tumour cells...
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Cancer vaccine shows promise for HER2-positive cancers
Treatment with a HER2-targeted therapeutic cancer vaccine provided clinical benefit to several patients with metastatic HER2-positive cancers...
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Synthetic biology in drug discovery
Synthetic biology is broadly defined as the design and construction of novel artificial biological pathways, organisms or devices; or the redesign of existing natural biological systems.1 It brings together a range of disciplines and skills, from biology and chemistry to computing, bioinformatics and engineering.
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What happens to skin cells when they are confronted with blood?
Researchers have performed experiments on blood-deprived cells that were subsequently exposed to blood serum, revealing new insights into the mechanisms of wound healing...
