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Study suggests PD-1 inhibitors against aggressive pediatric brain cancer subtype
A study has laid the groundwork for the use of PD-1 inhibitors with an aggressive form of brain cancer, namely supratentorial pediatric ependymoma.
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Immunology
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Immune cells dictate tumour progression
Analysing individuals' genotypes and immunotypes could yield customised treatments for prostate cancer...
whitepaper
Application note: Development and utilisation of bromodomain and extra terminal domain (BET) assays using AlphaLISA technology
In this application note, PerkinElmer demonstrates the ease and utility of using AlphaLISA®, a homogeneous assay format, to screen for small molecular inhibitors of BET bromodomains.
webinar
Using open science to develop Pediatric Cancer Drugs
2 January 2018 | By Charles River Laboratories
The webinar speakers highlight the collaboration between patient groups, charities, and academia led to the development of inhibitors targeting gliomas.
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Researchers create anti-inflammatory antibodies to treat autoimmune disease
Massachusetts General Hospital (MGH) investigators use enzyme treatment to convert autoantibodies into anti-inflammatory antibodies in animal models of two autoimmune diseases.
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Stem cell-derived intestine model mimics innate immune responses
A stem cell-derived in vitro model displays key small intestine characteristics including innate immune responses.
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Mature B lymphocytes accelerate the healing of acute and chronic wounds
Direct application of immune cells speeds and improves healing of acute and chronic wounds in animal models...
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DNA-based Zika vaccine found effective at inducing immune response
A new generation DNA-based Zika vaccine is the first to demonstrate both safety and the ability to elicit an immune response against Zika in humans...
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Cytokine molecules unearth development of progressive MS
Scientists have uncovered two closely related cytokines molecules involved in cell communication that explain why some people develop progressive MS...
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New metabolic target in quest to control immune response
Immune cells could help to increase immune activity in vaccines or suppress immune reactions in autoimmune diseases...
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Researchers identify a new way to treat HIV
Researchers have identified a novel variant "Delta 20" that suppresses the most damaging HIV strains...
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New test for rare immunodeficiency
Researchers have developed a test to diagnose a rare and severe immune defect...
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Immune system can be modulated by targeted manipulation
Manipulation of the sugar metabolism and associated modulation of the immune system could open up new options for treating specific infectious and also autoimmune diseases...
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New marker could refine the process of producing hPSC-derived insulin cells
Scientists at the University of Copenhagen have identified a unique cell surface protein present on human pancreatic precursor cells providing for the first time a molecular handle to purify the cells whose fate is to become cells of the pancreas - including insulin producing cells.
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Immune system may mount an attack in Parkinson’s disease
T cells may play an important role in Parkinson’s disease (PD), according to a new study...