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Immuno-oncology

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Scientists uncover answer to colorectal cancer immunotherapy resistance

13 October 2021 | By Anna Begley (Drug Target Review)

Boosting dendritic cells prevented immunotherapy resistance in mouse models, suggesting a new approach to colorectal cancer therapies.

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Antidepressants inhibit growth of pancreatic and colon cancers in mice

29 September 2021 | By Anna Begley (Drug Target Review)

Scientists have discovered that approved antidepressant drugs cause immune cells to recognise and eliminate tumour cells in mouse models.

news

“Ultrasensitive” HPV detection paves way for precision treatment

28 September 2021 | By Anna Begley (Drug Target Review)

A new study sequenced tumour DNA for the “ultrasensitive” detection of HPV, further honing precision treatment of the illness.

news

New AI method could aid in development of T cell-based cancer therapies

24 September 2021 | By Anna Begley (Drug Target Review)

An artificial intelligence technique can identify which neoantigens are recognised by the immune system, possibly improving cancer prognosis and treatment.

news

Club cell factors may reverse immune suppression in tumours

21 September 2021 | By Anna Begley (Drug Target Review)

New research has revealed that club cells secret anti-immunosuppressive factors in tumours, potentially revolutionising cancer therapies.

news

Controlling PTEN gene could combat paediatric rhabdomyosarcoma

20 September 2021 | By Anna Begley (Drug Target Review)

The decreased expression of PTEN in mouse models was found to make rhabdomyosarcoma tumours more aggressive, highlighting new treatment approaches.

whitepaper

Cell & Gene Therapy Advancements Whitepaper

16 September 2021 | By Drug Target Review

Download this whitepaper to discover the latest research and developments in cell and gene therapies via exclusive articles and interviews.

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Novel tool can estimate number of T cells in cancer tumours

10 September 2021 | By Anna Begley (Drug Target Review)

Researchers have developed a new method that can rapidly count the number of T cells in a tumour, helping to predict patient response to therapies.

news

STING-activating drugs could customise cancer treatments

9 September 2021 | By Anna Begley (Drug Target Review)

An imaging technique identified emerging drugs that activate the STING protein to alter metabolic pathway activity in cancer cells.

news

Stem-like T cells could improve immunotherapy treatments

7 September 2021 | By Anna Begley (Drug Target Review)

Targeting stem-like T cells within certain lymph nodes could improve the number of cancer patients that respond to immunotherapy treatments.

news

RN7SL1 RNA shown to activate T cells to fight against cancer

6 September 2021 | By Anna Begley (Drug Target Review)

A new study found that the RNA RN7SL1 can activate T cells to seek out cancer cells, potentially improving cellular treatments.

video

Drug Target Review update: exclusive report, online summit and more!

25 August 2021 | By Drug Target Review

Hear about the latest Drug Target Review updates from Deputy Editor Victoria Rees who discusses our new report on AI & Informatics, the Cell & Gene Therapy Advancements online summit and much more!

news

High-intensity focused ultrasound therapy moves closer to the clinic

24 August 2021 | By Anna Begley (Drug Target Review)

Researchers are investigating how high-intensity focused ultrasound (HIFU) can work on a cellular level to treat a range of cancers.

White blood cells as part of immune response to leukaemia

news

Existing drug may improve immune response to leukaemia treatment

18 August 2021 | By Anna Begley (Drug Target Review)

Researchers identified the inhibitor JQ1 as a potential drug to improve immune response to CAR T-cell therapies in leukaemia patients.

news

Enzyme discovery could fight against cancer and viral infections

17 August 2021 | By Anna Begley (Drug Target Review)

A new study has identified a vital enzyme, known as APOBEC3A, that could lead to new treatments against cancers and viral infections.

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Immuno-oncology