news
Discovery could advance CAR T-cell therapy
Scientists have found a way to “supercharge” tumour-attacking T cells, which could improve the effectiveness of cell-based cancer immunotherapy and expand the number of cancers it can treat.
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Immuno-oncology
news
Novel CAR T-cell therapy for B-cell cancers shows promise in vivo
A new CAR T-cell therapy for B-cell cancers promises to reduce the antigen escape currently found in therapies that only target CD19.
article
T-cell immunotherapies and flow cytometry
Dr Alasdair Gunn and Natalie Bath from Adaptimmune explain how flow cytometry provides a useful tool for the development of immuno-oncology therapies. They also explore how they use this method for translational research of the company’s SPEAR T-cell products.
article
Drug Target Review Flow Cytometry ebook 2021
This ebook includes articles on flow cytometry in drug discovery and how it is applied to leishmaniasis research. Also included is a piece on how flow cytometry is being used to support the translational research of immuno-oncology therapies.
article
“Off-the-shelf” immunotherapies for cancer
In this article, Drug Target Review's Victoria Rees explores a new method that could enable powerful immune cells to be produced in large quantities to treat a range of cancers.
news
New class of CAR T cells combat previously “untargetable” cancer drivers
The peptide-centric chimeric antigen receptors killed neuroblastoma cells in mice and could potentially expand the pool of immunotherapeutic targets.
news
Experimental drug boosts immunotherapy efficacy for pancreatic cancer
An experimental drug enhanced the benefit of immunotherapy, reducing and in some cases eliminating pancreatic cancer in mice.
podcasts
Episode 3 – Cell & gene therapy with Dr Sam Wadsworth, Ultragenyx Pharmaceutical & Dr Eric Ostertag, Poseida Therapeutics
Tune in to this podcast to learn about AAV vectors for gene therapy delivery and engineering CAR T cells against solid tumours.
news
Raman spectroscopy used to determine immunotherapy effectiveness
Researchers used Raman spectroscopy to monitor immunotherapy response in mice, potentially improving cancer treatments in the future.
video
Engineering better CAR T cells with Professor Ann Ager, Cardiff University
Watch this exclusive interview with Professor Ann Ager, Cardiff University, to discover how CAR T cells could be targeted against solid tumours.
news
Medicenna’s MDNA11 a promising alternative to checkpoint inhibitors
Medicenna's IL-2 super-agonist, MDNA11, successfully induced antitumour cells in animal models, a pre-clinical study has revealed.
news
Scientists uncover answer to colorectal cancer immunotherapy resistance
Boosting dendritic cells prevented immunotherapy resistance in mouse models, suggesting a new approach to colorectal cancer therapies.
news
Antidepressants inhibit growth of pancreatic and colon cancers in mice
Scientists have discovered that approved antidepressant drugs cause immune cells to recognise and eliminate tumour cells in mouse models.
news
“Ultrasensitive” HPV detection paves way for precision treatment
A new study sequenced tumour DNA for the “ultrasensitive” detection of HPV, further honing precision treatment of the illness.
news
New AI method could aid in development of T cell-based cancer therapies
An artificial intelligence technique can identify which neoantigens are recognised by the immune system, possibly improving cancer prognosis and treatment.
