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Immuno-oncology

T-cells attacking cancer cell illustration of microscopic photos

Keeping T cells strong and improving cancer immunotherapy

8 December 2022 | By Dr Brian Shy (UCSF)

The tumour microenvironment can prevent some T cells from carrying out their immunotherapeutic duties. In this Q&A, Dr Brian Shy, Clinical Instructor at the University of California, San Francisco (UCSF) Department of Laboratory Medicine, describes a recent study wherein he and fellow scientists discovered a strategy to strengthen T cells…

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Drug Target Review Immuno-oncology ebook 2022

7 December 2022 | By Drug Target Review

In this ebook are articles on immune checkpoint inhibitors and enhancing CAR T-cell therapies.

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Drug Target Review – Issue 4 2022

6 December 2022 | By Drug Target Review

A new Drug Target Review issue is now ready to download! This issue features articles which explore how artificial intelligence can enhance screening and ways to find new hits through simultaneous orthogonal screens. Also included are articles on CRISPR, immuno-oncology and RSV vaccines.

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Novel nanoparticles deliver innovative cancer chemoimmunotherapy

1 December 2022 | By Izzy Wood (Drug Target Review)

University of Pittsburgh researchers have designed cancer-fighting nanoparticles that co-deliver a chemotherapy drug and a novel immunotherapy

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Novel ‘prodrug’ designed to eliminate cancer without harming healthy cells

23 November 2022 | By Izzy Wood (Drug Target Review)

US researchers discovered in a study in mice that augmented drug eliminates cancer cells without causing toxicity.

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Bacteria in a tumour’s microbiome could influence how cancer responds to treatment

23 November 2022 | By Izzy Wood (Drug Target Review)

US researchers find that bacteria could help tumours progress and resist treatment.

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Cancer immunotherapy adapted to treat COVID-19 variants

22 November 2022 | By Izzy Wood (Drug Target Review)

US researchers have utilised a cancer immunotherapy technique, CAR-T cell method to effectively eliminate SARS-CoV-2 virus pre- and post-infection in vitro.

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New MACHETE technique developed to slice into cancer genome

21 November 2022 | By Izzy Wood (Drug Target Review)

Sloan Kettering Institute (SKI) researchers have developed a new machete technique to slice into the cancer genome and study copy number alterations.

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Five recent CRISPR drug target discoveries

21 November 2022 | By Izzy Wood (Drug Target Review)

This article highlights five of the latest findings revealed using CRISPR that could be used in the development or design of new therapies.

CAR T-Cell Therapy. T-Cell binding to a tumour cell using Chimeric Antigen Receptor (CAR)

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Novel CAR T screens identify most effective cancer immunotherapy cells

11 November 2022 | By Ria Kakkad (Drug Target Review)

Researchers have developed a new method for comparing CAR T cells, each with slightly different molecular features, to determine which is most effective and long-lasting against cancer.

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Nanotechnology platform sensitises cancer to immunotherapy

11 November 2022 | By Victoria Rees (Drug Target Review)

A new pre-clinical study has utilised nanoparticles to attach immune-activating molecules to cancer cells.

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Experimental cancer vaccine shows promise in animal studies

11 November 2022 | By Victoria Rees (Drug Target Review)

NIH researchers who intravenously delivered a cancer vaccine to mice report that it increased the number of T cells able to combat tumours.

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Protein inhibitor could be new treatment for liver cancer

8 November 2022 | By Izzy Wood (Drug Target Review)

US scientists have found strong evidence for testing VCU-manufactured drugs in liver cancer.

Genome data. Genetics sequence barcode visualisation, dna test and genetic medical sequencing map. Genomics genealogy sequencing data, chromosome architecture vector concept illustration

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DNA barcoding reveals cancer cells’ ability to evade the immune system

7 November 2022 | By Ria Kakkad (Drug Target Review)

Using DNA barcoding to track cancer cells through time, scientists have shown that the cells have diverse abilities to escape the immune system.

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Cancer therapy shows potential to treat severe COVID-19 patients

28 October 2022 | By Izzy Wood (Drug Target Review)

Pre-clinical experiments involving cells from ICUs patients infected by SARS-CoV-2, and mice infected by MHV-A59 (murine hepatitis virus A59) show promise in treating COVID-19.

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Immuno-oncology