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Researchers find drug improves cancer immunotherapy in mice
A study has shown that in mice, the GKT137831 drug makes tumours more sensitive to immunotherapy, so could be used to improve cancer treatments.
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Immunotherapy
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New T-cell discovery could lead to treatments for both bacterial infections and autoimmune conditions
A novel highly activated form of T cells could be suppressed to treat autoimmune conditions and activated in treating bacterial infections.
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Boosting natural killer cells in mice with eczema relieves condition
Researchers have found that using IL-15 to boost natural killer cell numbers in mice helps to combat eczema and could be a therapeutic strategy for patients.
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ILC2s sensitise pancreatic tumours to PD-1 checkpoint inhibitors in mice
Scientists identify innate lymphoid cells (ILCs) as possible targets for immunotherapies as their activation makes murine pancreatic tumours sensitive to PD-1 checkpoint inhibitors.
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Targeting CD36 with antibody inhibits Treg tumour protection in mice
Researchers have discovered that an antibody which targets the CD36 protein prevents Tregs from protecting tumours against immunotherapies in mouse models.
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APOBEC3B genetic mutation signatures could be used to target cancers
An innovative new vaccine technique, which sensitises the immune system to the genetic signature of APOBEC mutations (often found in cancers), increases the efficacy of immunotherapies.
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Nanoparticles could be an alternative to antibody immunotherapies
A study has shown that inexpensive nanoparticles can effectively inhibit PD-L1 in cancer cells in the lab and work as well as antibodies, providing a potential alternative immunotherapy.
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Immune cell autophagy discovery could optimise cancer therapies
Researchers reveal importance of IL-15 in T cell autophagy in the liver, presenting a potential strategy to enhance immunotherapies.
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New T-cell therapy could provide universal cancer treatment
Researchers have discovered a new type of T-cell receptor that can kill most cancer types while leaving healthy cells unharmed.
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Researchers find VISTA molecule silences immune system against cancer
A new study shows that the VISTA molecule stops the immune system responding to self-antigens, including those presented by cancer cells, so an anti-VISTA antibody could be a possible therapy.
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Cancer cells killed in mice using copper-based nanomaterials
Copper oxide nanoparticles have successfully killed tumour cells in mice and when combined with immunotherapy, could work as a vaccine for cancer.
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Immune cells grown in dish from pluripotent stem cells
In a world first, researchers have grown immune cells from pluripotent stem cells in a dish, which could be used to develop immunotherapies or to test autoimmune disease treatments.
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New compounds developed to block cancer growth regulator FOXM1
A study has demonstrated the success of new compounds that prevent FOXM1, a transcription factor, from increasing cancer proliferation.
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HDAC3 inhibitors: a potential treatment for non-Hodgkin lymphomas?
A murine study found histone deacetylase 3 (HDAC3) inhibitors reverse epigenetic changes caused by CREBBP mutations found in lymphomas and could be developed into a novel therapy.
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Siah2 protein discovered as a regulator of the immune system
A new study has revealed that the Siah2 protein is crucial to control Tregs in mice, which can reduce the effectiveness of immunotherapies.