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In Vivo

Black and red capsules in a pile with top one labelled 'COVID-19' in white writing - idea of a tablet/pill COVVID-19 vaccine

news

COVID-19 vaccine tablet significantly reduces viral load in hamsters

17 November 2020 | By Hannah Balfour (Drug Target Review)

Hamster challenge study results suggests the oral COVID-19 vaccine induces a robust immune response, protecting the animals from infection.

cancerous cell with crosshares over it - idea of targetted cancer therapy

news

LMTK3 inhibitors could be an effective breast cancer therapy, say scientists

16 November 2020 | By Hannah Balfour (Drug Target Review)

Researchers demonstrate that inhibiting the LMTK3 kinase is an effective anticancer strategy in murine models of breast cancer.

news

Primate model used to explore features of SARS-CoV-2 infection

16 November 2020 | By Hannah Balfour (Drug Target Review)

The non-human primate model exhibited a COVID-19-like disease and showed how symptoms and viral activity change over the course of SARS-CoV-2 infection.

MRI of a glioblastoma in the brain of a patient (in frontal lobe near the right eye)

news

Novel nanoparticle therapy shows promise in glioblastoma

11 November 2020 | By Hannah Balfour (Drug Target Review)

The synthetic protein nanoparticle can cross the blood-brain barrier and deliver a targeted therapeutic to glioblastoma cells, say researchers.

Close up graphic of SARS-CoV-2 particle in grey, with red spike proteins, binding to a yellow cell surface ACE2 receptor

news

Researchers develop ACE2 decoy to neutralise SARS-CoV-2

10 November 2020 | By Hannah Balfour (Drug Target Review)

Using their de novo protein design strategy, researchers engineered human angiotensin converting enzyme 2 (hACE2) protein decoys that can protect cells from SARS-CoV-2 infection.

3D rendering of a human torso with anatomically correct lungs highlighted in orange

news

T cells facilitate chronic lung injury in the elderly after viral infections, finds study

10 November 2020 | By Hannah Balfour (Drug Target Review)

After viral pneumonia in elderly mice, there is an accumulation of dysfunctional tissue-resident memory T cells in the lungs which scientists suggest may drive chronic inflammation and fibrosis.

Three-dimensional (3D) illustration of amyloid beta plaques (brown mesh-like shapes) forming between neurons and disrupting their function. Amyloid plaques are a hallmark of Alzheimer’s Disease.

news

Developing drugs for disordered proteins

6 November 2020 | By Hannah Balfour (Drug Target Review)

Scientists have developed a drug-like molecule to target amyloid-beta, a disordered protein implicated in Alzheimer's disease that has been considered undruggable.

Human torso outlined in glowing blue with lungs visible and major airways outlined in pink

news

Novel therapeutic approach shows promise in mice with COPD

5 November 2020 | By Hannah Balfour (Drug Target Review)

By blocking the lymphotoxin beta receptor signalling pathway, researchers were able to prevent COPD progression and induce a full restoration of lung tissue.

woman scratching the back of her leg while walking on grass - idea of allergic reaction itching

news

Researchers reveal how allergens may trigger itching

2 November 2020 | By Hannah Balfour (Drug Target Review)

Certain sensory neurons and Substance P are potential drug targets for the development of novel allergy preventions or treatments, according to scientists.

red immune cell attacking a blue cancer cell on a dark blue background

news

Researchers develop novel class of cancer immunotherapy

30 October 2020 | By Hannah Balfour (Drug Target Review)

The scientists developed a therapy which uses nanobiologics to train the innate immune system to recognise and combat cancer cells.

news

Novel anti-inflammatory slows progression of MS in mice

22 October 2020 | By Hannah Balfour (Drug Target Review)

When delivered intranasally, the anti-inflammatory drug VX-765 prevented axon demyelination and loss in a murine model of multiple sclerosis (MS).

glass vial labelled 'Alzheimer's Vaccine'

news

Novel Alzheimer’s vaccine shows promise in murine models

21 October 2020 | By Hannah Balfour (Drug Target Review)

Scientists who developed the E22W42 DC vaccine suggest it could be safer and more effective than previous anti-amyloid Alzheimer’s therapies.

RNA strands in orange on a blue background

news

Novel siRNA therapy improves psoriasis in mice

19 October 2020 | By Hannah Balfour (Drug Target Review)

Topical delivery of a small interfering RNA (siRNA) using an ionic liquid complex significantly reduced levels of inflammatory cytokines and symptoms of psoriasis.

Wasp on a wooden platform [Credit: University of Pennsylvania].

news

Novel antimicrobial molecules derived from wasp venom

13 October 2020 | By Hannah Balfour (Drug Target Review)

Altering the mastoparan-L (mast-L) peptide found in Vespula lewisii wasp venom, researchers created several novel antimicrobial molecules.

news

Researchers uncover drivers of memory B cell formation

13 October 2020 | By Hannah Balfour (Drug Target Review)

The team demonstrated that expression of Bach2 protein and reduced mTORC1 activity is necessary for germinal B cells to become memory B cells.

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In Vivo