news
Using microgravity to address limitations of tissue engineering techniques
The self-assembly of human liver tissues in low Earth orbit could improve their differentiation and functionality.
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Induced Pluripotent Stem Cells (iPSCs)
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New agreement to progress cardiovascular disease research
The agreement between Cartherics, The University of Sydney and The University of Queensland will further stem cell-derived heart muscle therapy for heart failure.
news
Treating HCC with genetically modified NK-cell therapy
Blocking the TGF-β signalling pathway produced effective antitumour activity against hepatocellular carcinoma.
article
Brain organoids: a fascinating and powerful tool for drug discovery
Human brain organoids are complex in vitro tools derived from stem cells, designed to model the molecular basis of neurodevelopment and the pathogenesis of neurological disorders. By mimicking the function of the human brain, in both health and disease, their application in drug discovery holds significant potential for identifying new…
news
Elucidating the loss of mobility caused by LGMD2B
The hiPSC-derived skeletal muscle model is the first to uncover the biological mechanisms underlying loss of mobility.
news
Werner syndrome: mechanism behind atherosclerosis elucidated
Researchers have developed a new in vitro co-culture system which enables an in-depth molecular analysis of atherosclerosis.
news
Enhanced NPC cultivation furthers understanding of kidney disease
Induced NPCs facilitate the creation of patient-specific organoid models and improve identification of nephron targeted drugs.
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Accelerating cardiac regenerative therapy with HiPSC spheroids
Injections of cardiac spheroids into primate ventricles improved left ventricular ejection after four weeks.
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iPSC-derived cells can augment remuscularisation of the heart
Researchers have improved the method of regenerating heart muscle after a heart attack using a combination of iPSC-derived cells.
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Human-derived proteins used in DREAM tool
CRISPR-DREAM tool used to activate insufficiently expressed genes and convert skin cells to induced pluripotent stem cells (iPSCs).
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Genome-edited iPSCs show promise for treating Fabry Disease
Japanese researchers successfully engineered iPSCs to secrete a modified enzyme, mNAGA, and restored enzyme activity in vitro and in a mouse model, opening new avenues for regenerative medicine for conditions such as Fabry Disease.
podcasts
Episode 19 – A current look into adoptive cell therapies
Tune into this podcast to hear experts discussing the current landscape of adoptive cell therapies!
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Framework for understanding cell organisation and variation
From a database of more than 200,000 high-resolution, three-dimensional images of human induced pluripotent stem cells, researchers have devised a model to quantify cell shape and internal organization. Susanne Rafelski, Deputy Director of the Allen Institute for Cell Science, revealed details of their study to Drug Target Review.
whitepaper
Under the microscope: Sustaining momentum in iPSC-derived allogeneic cell therapies
Drug Target Review connects with Dr Stefan Braam, co-founder and CTO of Cellistic, and Andy Holt, CCO of Cellistic, for a rundown on today’s landscape for allogeneic cell therapies.
news
New organoid emulates development of the human heart
The team are the first researchers in the world to successfully create an organoid containing both heart muscle cells and cells of the outer layer of the heart wall.